Kremer David S, Gatmaytan Pauline Elizabeth, Rübel Michelle Amanda, Flahault Antoine, Hasselgard-Rowe Jennifer
Global Studies Institute, University of Geneva, 1205 Geneva, Switzerland.
Faculty of Medicine, Institute of Global Health, University of Geneva, 1211 Geneva, Switzerland.
Int J Environ Res Public Health. 2025 Jun 28;22(7):1036. doi: 10.3390/ijerph22071036.
This study aimed to identify and synthesize the success metrics used to assess hepatitis C elimination among people who inject drugs (PWID) through harm reduction strategies. A scoping review was performed by searching across three databases to identify systematic reviews that discussed hepatitis C in PWID within the context of harm reduction. The studies were then analyzed for success metrics used to describe hepatitis C in PWID. The indicators used were prevalence, incidence, screening, treatment uptake, treatment completion, and sustained virologic response. A total of fourteen systematic reviews were included. The most frequently reported indicators were prevalence and incidence, addressed in eight/seven systematic reviews, respectively. In contrast, screening, treatment uptake, and treatment completion were less commonly reported, with only two reviews addressing screening and treatment uptake, and a single review reporting treatment completion. Similarly, sustained virologic response (SVR) was reported in only two systematic reviews. Seven additional indicators were reported. Prevalence and incidence are the dominantly used HCV indicators, while others are often neglected. Inconsistencies in measurements and reporting can be found for all indicators. This study reports a gap regarding indicators beyond prevalence and incidence, inconsistent measurement approaches, and a lack of standardized frameworks.
本研究旨在识别和综合用于通过减少伤害策略评估注射吸毒者（PWID）丙型肝炎消除情况的成功指标。通过在三个数据库中进行检索，开展了一项范围综述，以识别在减少伤害背景下讨论PWID丙型肝炎的系统综述。然后对这些研究进行分析，以确定用于描述PWID丙型肝炎的成功指标。所使用的指标包括患病率、发病率、筛查、治疗接受情况、治疗完成情况和持续病毒学应答。总共纳入了14项系统综述。最常报告的指标是患病率和发病率，分别在8/7项系统综述中涉及。相比之下，筛查、治疗接受情况和治疗完成情况的报告较少，仅有两项综述涉及筛查和治疗接受情况，一项综述报告了治疗完成情况。同样，只有两项系统综述报告了持续病毒学应答（SVR）。还报告了另外七个指标。患病率和发病率是主要使用的丙型肝炎病毒指标，而其他指标常常被忽视。所有指标在测量和报告方面都存在不一致之处。本研究报告了在患病率和发病率之外的指标、不一致的测量方法以及缺乏标准化框架方面的差距。
