Department of Natural Medicinal Chemistry and Pharmacognosy, School of Pharmacy, Qingdao University, Qingdao 266071, China.
Department of Natural Product Chemistry, Key Laboratory of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China.
J Asian Nat Prod Res. 2021 Dec;23(12):1148-1155. doi: 10.1080/10286020.2020.1866559. Epub 2021 Jan 16.
Fusidic acid, a representative member of fungal fusidane triterpenoids, has been clinically used as an antibiotic. In the present study, fusidic acid (), and its known analogs 16-desacetylfusidic acid () and 3,20-dihydroxy-protosta-16,24-dien-29-oic acid (), together with one new derivative acremonidiol A (), were isolated from the endophytic fungus, F47. Their structures were determined by MS and NMR. The spectroscopic data of are firstly reported here. The antibacterial efficacies of - were evaluated against four selected Gram-positive or Gram-negative bacteria. As expected, only compound showed strong inhibitory effect on Gram-positive bacteria and .
夫西地酸是真菌夫烷三萜类的代表性成员，临床上用作抗生素。本研究从内生真菌 F47 中分离得到夫西地酸（）及其已知类似物 16-去乙酰夫西地酸（）和 3,20-二羟基-原甾烷-16,24-二烯-29-酸（），以及一个新的衍生物 acremonidiol A（）。通过 MS 和 NMR 确定了它们的结构。这里首次报道了的光谱数据。-的抗菌活性被评估对四种选定的革兰氏阳性或革兰氏阴性细菌。正如预期的那样，只有化合物 对革兰氏阳性菌 和 表现出强烈的抑制作用。
