Lin Chih-Lang, Liu Jun-Ting, Shin Chow-Shing
Center for General Education, Central Taiwan University of Science and Technology, Taichung City 40601, Taiwan.
Department of Automatic Control Engineering, Feng Chia University, Taichung City 407802, Taiwan.
Micromachines (Basel). 2025 Jun 29;16(7):762. doi: 10.3390/mi16070762.
As three-dimensional (3D) printing becomes increasingly prevalent in microfluidic system fabrication, the demand for high precision has become critical. Among various 3D printing technologies, light-curing-based methods offer superior resolution and are particularly well suited for fabricating microfluidic channels and associated micron-scale components. Two-photon polymerization (TPP), one such method, can achieve ultra-high resolution at the submicron level. However, its severely limited printable volume and high operational costs significantly constrain its practicality for real-world applications. In contrast, digital light processing (DLP) 3D printing provides a more balanced alternative, offering operational convenience, lower cost, and print dimensions that are more compatible with practical microfluidic needs. Despite these advantages, most commercial DLP systems still struggle to fabricate intricate, high-resolution structures-particularly curve, thin-walled, or hollow ones-due to over-curing and interlayer adhesion issues. In this study, we developed a DLP-based projection micro-stereolithography (PμSL) system with a simple optical reconfiguration and fine-tuned its parameters to overcome limitations in printing precise and intricate structures. For demonstration, we selected an Archimedes microscrew as the target structure, as it serves as a key component in microfluidic micromixers. Based on our previous study, the most effective design was selected and fabricated in accordance with practical microfluidic dimensions. The PμSL system developed in this study, along with optimized parameters, provides a reference for applying DLP 3D printing in high-precision microfabrication and advancing microfluidic component development.
随着三维(3D)打印在微流控系统制造中越来越普遍,对高精度的需求变得至关重要。在各种3D打印技术中,基于光固化的方法具有卓越的分辨率,特别适合制造微流控通道及相关的微米级部件。双光子聚合(TPP)就是这样一种方法,它可以在亚微米级别实现超高分辨率。然而,其可打印体积严重受限且操作成本高昂,这极大地限制了它在实际应用中的实用性。相比之下,数字光处理(DLP)3D打印提供了一种更平衡的选择,具有操作便利性、成本较低以及打印尺寸更符合实际微流控需求等优点。尽管有这些优势,但由于过度固化和层间粘附问题,大多数商用DLP系统在制造复杂的高分辨率结构(特别是曲线形、薄壁或空心结构)时仍面临困难。在本研究中,我们开发了一种基于DLP的投影微立体光刻(PμSL)系统,通过简单的光学重新配置并对其参数进行微调,以克服在打印精确和复杂结构方面的限制。为了进行演示,我们选择阿基米德微螺旋作为目标结构,因为它是微流控微混合器中的关键部件。基于我们之前的研究,选择了最有效的设计,并根据实际微流控尺寸进行制造。本研究中开发的PμSL系统以及优化的参数,为在高精度微制造中应用DLP 3D打印和推进微流控部件开发提供了参考。