Department of Chemistry and Biochemistry, University of Maryland Baltimore County, Baltimore, MD, 21250, USA.
Anal Methods. 2022 Aug 4;14(30):2885-2906. doi: 10.1039/d2ay00798c.
This review paper examines recent (mostly 2018 or later) advancements in 3D printed microfluidics. Microfluidic devices are widely applied in various fields such as drug delivery, point-of-care diagnosis, and bioanalytical research. In addition to soft lithography, 3D printing has become an appealing technology to develop microfluidics recently. In this work, three main 3D printing technologies, stereolithography, fused filament deposition, and polyjet, which are commonly used to fabricate microfluidic devices, are thoroughly discussed. The advantages, limitations, and recent microfluidic applications are analyzed. New technical advancements within these technology frameworks are also summarized, which are especially suitable for microfluidic development. Next, new emerging 3D-printing technologies are introduced, including the direct printing of polydimethylsiloxane (PDMS), glass, and biopolymers. Although limited microfluidic applications based on these technologies can be found in the literature, they show high potential to revolutionize the next generation of 3D-printed microfluidic apparatus.
这篇综述论文考察了最近（主要是 2018 年或之后）在 3D 打印微流控方面的进展。微流控器件广泛应用于药物输送、即时诊断和生物分析研究等多个领域。除了软光刻技术外，3D 打印最近也成为了开发微流控的一种有吸引力的技术。在这项工作中，我们深入讨论了三种主要的 3D 打印技术，立体光刻、熔融沉积成型和多射流技术，这些技术常用于制造微流控器件。分析了它们的优点、局限性和最近的微流控应用。还总结了这些技术框架内的新技术进展，这些进展特别适合微流控的发展。接下来，介绍了一些新兴的 3D 打印技术，包括直接打印聚二甲基硅氧烷（PDMS）、玻璃和生物聚合物。尽管基于这些技术的微流控应用在文献中有限，但它们显示出了极大的潜力，可以推动下一代 3D 打印微流控设备的发展。
