An In Vitro Evaluation of the Effect of Ceramic Material, Surface Treatment, and Adhesive Cement on Shear Bond Strength in Prosthodontics.

: Ensuring the optimal shear bond strength (SBS) is essential for the long-term success of prosthodontic restorations. Our in vitro study aimed to evaluate the SBS of three types of ceramics (feldspathic, alumina, and lithium disilicates) using three adhesive cements (Variolink Esthetic LC, Variolink Esthetic DC, and Maxcem Elite). : Healthy molars were prepared, and ceramic blocks were cemented following universally accepted luting protocols. SBS tests were performed using a custom-made testing machine. A multiple linear regression model assessed the effects of ceramic type, surface treatment, and luting agent on SBS. : The regression model explained 61.3% of the variation in SBS values (R = 0.613); the adjusted R = 0.605 confirmed the model's robustness. The global F-test was statistically significant (F = 78.96, < 0.001). The total-etch technique (+4.47), the use of feldspathic ceramic, and 5% hydrofluoric acid treatment (+3.28) significantly affected SBS. Feldspathic ceramic and lithium disilicate showed superior performance against alumina. Light-cured and self-cured cement showed negative effects. : Ceramic material and cement type have combined effects on SBS. Optimal results were obtained with the total-etch technique, feldspathic ceramic, 5% hydrofluoric acid treatment, and dual-cured cement.