Lee Haeun, Roo Dayeon, Lee Dong-Geol, Kang Seunghyun, Min Jinwoo, Kang Heecheol, Heo Young Mok, Lee Kyung Eun
R&I Center, COSMAX BTI, Pangyo-ro 255, Bundang-gu, Seongnam 13486, Republic of Korea.
R&I Center, GFC Life Science, Dongtansunhwan-daero 823, Hwaseong 18471, Republic of Korea.
Microorganisms. 2025 Jul 3;13(7):1569. doi: 10.3390/microorganisms13071569.
Rising global temperatures increase skin exposure to heat stress, which can impair skin structure and function. While several cosmetic ingredients have been developed to mitigate heat-induced damage, most primarily aim to enhance hydration or suppress inflammation, lacking mechanistic insights into their action under heat stress. This study assessed -derived SUPER-T and its exosome form, Thermasome, in heat-stressed human skin fibroblasts. Transcriptomic profiling revealed that heat stress upregulated heat-related thermal receptors and downregulated key extracellular matrix (ECM)-related genes. Notably, treatment with SUPER-T upregulated expression of these genes, suggesting a reparative role as a barrier to alleviate heat stress at the dermal-epidermal junction. For its application in a field of cosmetics, SUPER-T encapsulated in exosomes (Thermasome) enhanced the heat resilience, suggesting its better transdermal and heat protective effects. Thermasome further improved skin heat resilience and enhanced ECM gene expression including collagen genes. Our findings provide a mechanistic basis for the development of functional cosmetical materials that target ECM remodeling under heat-stressed conditions.
全球气温上升增加了皮肤暴露于热应激的机会，这可能会损害皮肤的结构和功能。虽然已经开发了几种化妆品成分来减轻热诱导的损伤，但大多数主要旨在增强保湿或抑制炎症，缺乏对其在热应激下作用机制的深入了解。本研究评估了源自 的SUPER-T及其外泌体形式Thermasome对热应激的人皮肤成纤维细胞的影响。转录组分析表明，热应激上调了与热相关的热受体，并下调了关键的细胞外基质（ECM）相关基因。值得注意的是，用SUPER-T处理上调了这些基因的表达，表明其作为一种屏障具有修复作用，可减轻真皮-表皮交界处的热应激。对于其在化妆品领域的应用，封装在外泌体（Thermasome）中的SUPER-T增强了热弹性，表明其具有更好的透皮和热保护作用。Thermasome进一步提高了皮肤的热弹性，并增强了包括胶原蛋白基因在内的ECM基因表达。我们的研究结果为开发在热应激条件下针对ECM重塑的功能性化妆品材料提供了机制基础。
