Turska-Szybka Anna, Olczak-Kowalczyk Dorota, Twetman Svante
Department of Paediatric Dentistry, Medical University of Warsaw, Żwirki i Wigury St. 61, 02-091 Warsaw, Poland.
Department of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark Nørre Allé 20, 2200 Copenhagen, Denmark.
Nutrients. 2025 Jul 8;17(14):2253. doi: 10.3390/nu17142253.
BACKGROUND/OBJECTIVES: Children with an oral presence of spp. have an elevated prevalence of dental caries. As an alternative to conventional antifungal drugs, the use of biofilm-modulating strategies, such as probiotic bacteria, may be a sustainable option. Probiotics are live microorganisms that have beneficial health effects, while prebiotics are compounds in food that foster the growth or activity of the beneficial microorganisms. The aim of this paper was to review current clinical findings regarding the antifungal effects of pre- and probiotic supplements, including syn- and postbiotics, in children.
We searched two databases (PubMed and Google Scholar) for controlled clinical trials published in English up to 20 April 2025, and two authors scanned the abstracts independently for relevance. The selected full-text papers were reviewed and assessed for risk of bias.
Four articles published between 2013 and 2025 were included in this review, covering a total number of 208 caries-active children between 3 and 14 years of age. Study designs were heterogeneous, and we observed conflicting results: two studies with probiotic streptococci failed to demonstrate any beneficial effects on the counts of salivary , while interventions with and significantly reduced compared with controls. None of the included reports displayed a low risk of bias. No clinical studies utilizing prebiotics, synbiotics, or postbiotics were retrieved.
We found insufficient evidence concerning the antifungal effects of probiotic supplements in children. Therefore, we recommend future clinical trials to explore the ability of pre-, pro-, and postbiotic interventions to affect cross-kingdom biofilms in order to support a balanced and health-associated composition of the dental biofilm in children.
背景/目的：口腔中存在 菌属的儿童龋齿患病率较高。作为传统抗真菌药物的替代方法，使用生物膜调节策略，如益生菌，可能是一种可持续的选择。益生菌是对健康有益的活微生物，而益生元是食物中促进有益微生物生长或活性的化合物。本文旨在综述目前关于益生元和益生菌补充剂（包括合生元和后生元）对儿童抗真菌作用的临床研究结果。
我们在两个数据库（PubMed和谷歌学术）中检索截至2025年4月20日以英文发表的对照临床试验，两位作者独立筛选摘要以确定相关性。对选定的全文进行评审并评估偏倚风险。
本综述纳入了2013年至2025年间发表的4篇文章，共涉及208名3至14岁的龋齿活跃儿童。研究设计各不相同，我们观察到相互矛盾的结果：两项关于益生菌链球菌的研究未能证明对唾液 计数有任何有益影响，而与对照组相比，使用 和 的干预措施显著降低了 。纳入的报告均未显示低偏倚风险。未检索到使用益生元、合生元或后生元的临床研究。
我们发现关于益生菌补充剂对儿童抗真菌作用的证据不足。因此我们建议未来进行临床试验，以探索益生元、益生菌和后生元干预影响跨界生物膜的能力，以支持儿童口腔生物膜的平衡且与健康相关的组成。
