Man Vanessa C W, Manchanda Sheetal, Yiu Cynthia Ky
Paediatric Dentistry, Faculty of Dentistry, The University of Hong Kong, Sai Ying Pun, Hong Kong S.A.R.
Dental Public Health, Indiana University, Indianapolis, Indiana, USA.
Int Dent J. 2025 Apr;75(2):1246-1260. doi: 10.1016/j.identj.2024.08.020. Epub 2024 Sep 24.
Candida is a common fungal pathogen in the oral cavity, with Candida albicans being the most prevalent species. Some studies report a correlation between Candida prevalence and dental caries experience in preschoolers, while others report no such association. This systematic review and meta-analysis aimed to evaluate the association of Candida-biome with Early Childhood Caries (ECC) in preschool children.
Seven databases were searched for studies evaluating the correlation between Candida and ECC in healthy preschool children under 71 months of age. Dual independent screening, data extraction, bias risk assessment, meta-analysis, and quality evaluation of evidence were conducted.
The review included 20 studies with 12 reporting a positive association between Candida prevalence and ECC. The prevalence of Candida albicans in ECC ranged from 60%-84% across sample sites. Certain specific species, including C. dubliniensis and atypical non-albicans Candida (NAC), were also associated with caries severity in preschoolers. The pooled odds ratio (OR) estimate was 7.98 (95%CI; 3.84-16.58) for Candida-biome in plaque samples (I² = 84%), and 9.42 (95%CI: 4.15- 21.40) for Candida-biome in saliva sample (I² = 50%). These results suggest that children with Candida-biome in plaque and saliva have higher odds of having ECC than caries-free children.
Children with Candida-biome in plaque and saliva samples have a higher risk of Early Childhood Caries, predominantly associated with Candida albicans. Standardised methodologies for evaluating and comparing data on Candida species and ECC are recommended for future studies.
念珠菌是口腔中常见的真菌病原体，白色念珠菌是最普遍的种类。一些研究报告了学龄前儿童念珠菌感染率与龋齿经历之间的相关性，而其他研究则未发现这种关联。本系统评价和荟萃分析旨在评估念珠菌生物群与学龄前儿童早期龋（ECC）之间的关联。
检索了七个数据库，以查找评估71个月以下健康学龄前儿童念珠菌与ECC之间相关性的研究。进行了双人独立筛选、数据提取、偏倚风险评估、荟萃分析和证据质量评估。
该评价纳入了20项研究，其中12项报告念珠菌感染率与ECC之间存在正相关。在各个样本部位，ECC中白色念珠菌的感染率在60%-84%之间。某些特定种类，包括都柏林念珠菌和非典型非白色念珠菌（NAC），也与学龄前儿童的龋齿严重程度相关。菌斑样本中念珠菌生物群的合并比值比（OR）估计为7.98（95%CI；3.84-16.58）（I² = 84%），唾液样本中念珠菌生物群的合并比值比为9.42（95%CI：4.15-21.40）（I² = 50%）。这些结果表明，菌斑和唾液中存在念珠菌生物群的儿童患ECC的几率高于无龋齿儿童。
菌斑和唾液样本中存在念珠菌生物群的儿童患早期龋齿的风险更高，主要与白色念珠菌有关。建议未来的研究采用标准化方法评估和比较念珠菌种类和ECC的数据。
