State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, Sichuan University, Chengdu, China.
Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Front Cell Infect Microbiol. 2023 May 16;13:1151532. doi: 10.3389/fcimb.2023.1151532. eCollection 2023.
As one of the most common oral diseases in kids, early childhood caries affects the health of children throughout the world. Clinical investigations show the copresence of and in ECC lesions, and mechanistic studies reveal co-existence of and affects both of their cariogenicity. Clearly a comprehensive understanding of the interkingdom interaction between these two microorganisms has important implications for ECC treatment and prevention. To this end, this review summarizes advances in our understanding of the virulence of both and . More importantly, the synergistic and antagonistic interactions between these two microbes are discussed.
作为儿童中最常见的口腔疾病之一，幼儿龋齿影响着全世界儿童的健康。临床研究表明，和在 ECC 病变中同时存在，而机制研究表明，和的共存会影响它们的致龋性。显然，对这两种微生物之间的跨界相互作用的全面理解对 ECC 的治疗和预防具有重要意义。为此，本综述总结了我们对这两种微生物的毒力的理解进展。更重要的是，讨论了这两种微生物之间的协同和拮抗相互作用。
