Aggregation and adhesion ability of various probiotic strains and species: An study.

BACKGROUND/PURPOSE: The ability of probiotics to inhibit adhesion is a crucial characteristic that prevents colonization and infection progression. This study aimed to explore aggregation, adhesion, and cell surface characterization of probiotic and strains and to evaluate the effect of probiotics and their cell-free supernatants (CFSs) as postbiotics on adhesion to human oral keratinocytes.

MATERIALS AND METHODS

Eight probiotic strains and five reference strains were tested for autoaggregation, coaggregation, adhesin on human oral keratinocytes (H357), and cell surface properties. The anti- adhesion activities of probiotic strains and CFSs were investigated.

RESULTS

The results showed that most probiotics exhibited high adhesion to H357 cells, specifically oral probiotic SD4, SD7, and SD11, and adhesion ability of probiotic strains was strongly related to their autoaggregation, cell surface charges, and hydrophobicity. strains also revealed a high level of adhesion to H357 cells. and showed significantly higher adhesion abilities than others. After a combination of with probiotics or their CFSs, adhesion was significantly reduced. The anti- adhesion property of probiotics was strongly related to their autoaggregation, coaggregation, and adhesion abilities.

CONCLUSION

This study demonstrated that oral probiotic strains may be useful probiotics for preventing and treating oral candidiasis due to their high ability of aggregation, adhesion, and anti- adhesion to H357 cells.