Broeckel Jacob, Estes Landry, Leonard Megan, Dickerson Broderick L, Gonzalez Drew E, Purpura Martin, Jäger Ralf, Sowinski Ryan J, Rasmussen Christopher J, Kreider Richard B
Exercise & Sport Nutrition Laboratory, Human Clinical Research Facility, Department of Kinesiology and Sports Management, Texas A&M University, College Station, TX 77843, USA.
Increnovo LLC, Whitefish Bay, WI 53217, USA.
Nutrients. 2025 Jul 18;17(14):2365. doi: 10.3390/nu17142365.
Ginger contains gingerols, shagaols, paradols, gingerdiones, and terpenes, which have been shown to display anti-inflammatory properties and inhibit pain receptors. For this reason, ginger has been marketed as a natural analgesic. This study examined whether a specialized ginger extract obtained through supercritical CO extraction and subsequent fermentation affects pain perception, functional capacity, and markers of inflammation. Thirty men and women (56.0 ± 9.0 years, 164.4 ± 14 cm, 86.5 ± 20.9 kg, 31.0 ± 7.5 kg/m) with a history of mild to severe joint and muscle pain as well as inflammation participated in a placebo-controlled, randomized, parallel-arm study. Participants donated fasting blood, completed questionnaires, rated pain in the thighs to standardized pressure, and then completed squats/deep knee bends, while holding 30% of body mass, for 3 sets of 10 repetitions on days 0, 30, and 56 of supplementation. Participants repeated tests after 2 days of recovery following each testing session. Participants were matched by demographics and randomized to ingest 125 mg/d of a placebo or ginger (standardized to contain 10% total gingerols and no more than 3% total shogaols) for 58 days. Data were analyzed by a general linear model (GLM) analysis of variance with repeated measures, mean changes from the baseline with 95% confidence intervals, and chi-squared analysis. There was evidence that ginger supplementation attenuated perceptions of muscle pain in the vastus medialis; improved ratings of pain, stiffness, and functional capacity; and affected several inflammatory markers (e.g., IL-6, INF-ϒ, TNF-α, and C-Reactive Protein concentrations), particularly following two days of recovery from resistance exercise. There was also evidence that ginger supplementation increased eosinophils and was associated with less frequent but not significantly different use of over-the-counter analgesics. Ginger supplementation (125 mg/d, providing 12.5 mg/d of gingerols) appears to have some favorable effects on perceptions of pain, functional capacity, and inflammatory markers in men and women experiencing mild to moderate muscle and joint pain. Registered clinical trial #ISRCTN74292348.
生姜含有姜辣素、姜烯酚、姜酮、姜二酮和萜类化合物，这些成分已被证明具有抗炎特性并能抑制疼痛感受器。因此，生姜已作为一种天然镇痛药上市销售。本研究考察了通过超临界二氧化碳萃取及后续发酵得到的一种特制生姜提取物是否会影响疼痛感知、功能能力及炎症标志物。30名有轻至重度关节和肌肉疼痛以及炎症病史的男性和女性（年龄56.0±9.0岁，身高164.4±14厘米，体重86.5±20.9千克，体重指数31.0±7.5千克/平方米）参与了一项安慰剂对照、随机、平行组研究。参与者在补充剂服用的第0天、第30天和第56天进行空腹采血、填写问卷、对大腿受标准化压力时的疼痛进行评分，然后在负重30%体重的情况下完成深蹲/深膝弯曲，每组10次，共3组。每次测试后经过2天恢复，参与者重复测试。参与者根据人口统计学特征进行匹配，随机摄入125毫克/天的安慰剂或生姜（标准化为含有10%的总姜辣素且总姜烯酚含量不超过3%），持续58天。数据采用重复测量的一般线性模型（GLM）方差分析、95%置信区间下相对于基线的平均变化以及卡方分析进行分析。有证据表明，补充生姜可减轻股内侧肌的肌肉疼痛感知；改善疼痛、僵硬和功能能力评分；并影响多种炎症标志物（如白细胞介素-6、干扰素-γ、肿瘤坏死因子-α和C反应蛋白浓度），尤其是在抗阻运动恢复两天后。也有证据表明，补充生姜可增加嗜酸性粒细胞，并与非处方镇痛药使用频率降低有关，但差异不显著。补充生姜（125毫克/天，提供12.5毫克/天的姜辣素）似乎对轻至中度肌肉和关节疼痛的男性和女性的疼痛感知、功能能力及炎症标志物有一些有益影响。注册临床试验编号：#ISRCTN74292348 。
