Nutrition, Oxidative Stress and Bioavailability Group, Degree in Pharmacy, Faculty of Health Sciences, Catholic University of San Antonio de Murcia, 30107 Murcia, Spain.
Molecules. 2022 Oct 25;27(21):7223. doi: 10.3390/molecules27217223.
Ulcerative colitis, Crohn's disease, rheumatoid arthritis, psoriasis, and lupus erythematosus are some of common inflammatory diseases. These affections are highly disabling and share signals such as inflammatory sequences and immune dysregulation. The use of foods with anti-inflammatory properties such as ginger () could improve the quality of life of these patients. Ginger is a plant widely used and known by its bioactive compounds. There is enough evidence to prove that ginger possesses multiple biological activities, especially antioxidant and anti-inflammatory capacities. In this review, we summarize the current knowledge about the bioactive compounds of ginger and their role in the inflammatory process and its signaling pathways. We can conclude that the compounds 6-shoagol, zingerone, and 8-shoagol display promising results in human and animal models, reducing some of the main symptoms of some inflammatory diseases such as arthritis. For lupus, 6-gingerol demonstrated a protective attenuating neutrophil extracellular trap release in response to phosphodiesterase inhibition. Ginger decreases NF-kβ in psoriasis, and its short-term administration may be an alternative coadjuvant treatment. Ginger may exert a function of supplementation and protection against cancer. Furthermore, when receiving chemotherapy, ginger may reduce some symptoms of treatment (e.g., nausea).
溃疡性结肠炎、克罗恩病、类风湿性关节炎、银屑病和红斑狼疮是一些常见的炎症性疾病。这些疾病高度致残，并具有炎症序列和免疫失调等共同信号。使用具有抗炎特性的食物，如生姜（），可以提高这些患者的生活质量。生姜是一种广泛使用的植物，以其生物活性化合物而闻名。有足够的证据证明生姜具有多种生物活性，特别是抗氧化和抗炎能力。在这篇综述中，我们总结了生姜的生物活性化合物及其在炎症过程及其信号通路中的作用的最新知识。我们可以得出结论，6-姜酚、姜酮和 8-姜酚这三种化合物在人类和动物模型中显示出有希望的结果，可减轻关节炎等一些炎症性疾病的一些主要症状。对于狼疮，6-姜酚显示出对磷酸二酯酶抑制的中性粒细胞胞外陷阱释放的保护性衰减作用。生姜可降低银屑病中的 NF-kβ，其短期给药可能是一种替代的辅助治疗方法。生姜可能具有补充和预防癌症的作用。此外，在接受化疗时，生姜可能会减轻一些治疗症状（如恶心）。
