Irto Anna, Ielo Ileana, Bretti Clemente, Crea Francesco, De Stefano Concetta, Cigala Rosalia Maria
Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali, Università di Messina, Viale F. Stagno d'Alcontres, 31-98166 Messina, Italy.
Molecules. 2025 Jul 16;30(14):2991. doi: 10.3390/molecules30142991.
The interactions of Fe with some ligands (Tranexamic (), Indole-3-acetic (), and Aminomethylphosphonic () acids) of biological and environmental interest were studied. The speciation studies were performed in NaNO and NaCl using potentiometric and, only for , spectrophotometric titrations at = 298.15 K and 0.01 ≤ /mol dm ≤ 1.0. The proposed speciation models are as follows: Fe()H, Fe(), Fe()(OH), and Fe()(OH) for ; Fe() for ; and Fe()H, Fe()H, and Fe() for . A comparison of log for the common Fe species gives log = 6.56 and log = 14.84 (at = 1.00 mol dm and = 298.15 K), suggesting that has a higher complexing ability towards Fe than . The dependence on the ionic strength of the formation constants was modeled by means of a Debye-Hückel type equation and the SIT model, whilst the sequestering ability of the investigated ligands towards Fe was quantified at various pHs, ionic strengths, and in the different supporting electrolytes by means of an empirical pL parameter. To complete this study of the behavior of the different Fe/ligand systems, various simulations in biological fluids and natural waters were conducted.
研究了铁与一些具有生物学和环境意义的配体（氨甲环酸、吲哚 - 3 - 乙酸和氨基甲基膦酸）之间的相互作用。在298.15 K和0.01 ≤ /mol dm ≤ 1.0条件下，使用电位滴定法，并仅针对 采用分光光度滴定法，在硝酸钠和氯化钠中进行了物种形成研究。提出的物种形成模型如下：对于 ，有Fe()H、Fe()、Fe()(OH)和Fe()(OH)；对于 ，有Fe()；对于 ，有Fe()H、Fe()H和Fe()。对常见铁物种的log 进行比较，得到log = 6.56和log = 14.84（在 = 1.00 mol dm 和 = 298.15 K时），这表明 对铁的络合能力高于 。通过德拜 - 休克尔型方程和SIT模型对形成常数对离子强度的依赖性进行了建模，同时通过经验pL参数在不同pH值、离子强度以及不同支持电解质条件下对所研究配体对铁的螯合能力进行了量化。为了完成对不同铁/配体系统行为的这项研究，还在生物流体和天然水中进行了各种模拟。
