Zhao Ji, Zhang Xiang-Rong, Wu You, Liu Ying-Li, Liang Yan-Feng, Teng Yang
College of Pharmacy, Jiamusi University, Jiamusi 154007, China.
College of Basic Medicine, Jiamusi University, Jiamusi 154007, China.
Molecules. 2025 Jul 18;30(14):3017. doi: 10.3390/molecules30143017.
L. var. (Mast.) Makino (PAF), which is used in both food and medicine, has a long history of about 1800 years of application in China. There are many active constituents in the calyx of PAF. Physalins and physalins with a single oxygen bridge are the unique components of the PAF calyx. Physalins with multiple biological activities, including anticancer activity, antimicrobial activity, anti-inflammatory activity, etc., have been found. As such, physalins deserve to be studied further. In this study, we aimed to extract, separate, and identify the effective components of physalins from the calyx of PAF and investigate ability to inhibit the proliferation of tumor cell lines. Three new physalins, physalin VIII (), 3α-hydroxy-2,3,25,27-tetrahydro-4,7-didehydro-7-deoxyneophysalin A (), and physalin IX (), along with three known compounds, physalin L (), physalin D (), and alkekengilin A () were isolated from PAF calyxes. Physalin D was superior to the positive control drug cisplatin in inhibiting the proliferation of five tumor cell lines. The physalin compounds exhibited potential antitumor activity, being deemed worthy of further research in the fields of antitumor drug development and the application in health foods.
酸浆变种（酸浆）牧野（PAF），用于食品和医药，在中国已有约1800年的应用历史。PAF花萼中有许多活性成分。酸浆苦素和具有单个氧桥的酸浆苦素是PAF花萼的独特成分。已发现具有多种生物活性的酸浆苦素，包括抗癌活性、抗菌活性、抗炎活性等。因此，酸浆苦素值得进一步研究。在本研究中，我们旨在从PAF花萼中提取、分离和鉴定酸浆苦素的有效成分，并研究其抑制肿瘤细胞系增殖的能力。从PAF花萼中分离出三种新的酸浆苦素，酸浆苦素VIII（）、3α-羟基-2,3,25,27-四氢-4,7-二脱氢-7-脱氧新酸浆苦素A（）和酸浆苦素IX（），以及三种已知化合物，酸浆苦素L（）、酸浆苦素D（）和酸浆烯吉灵A（）。酸浆苦素D在抑制五种肿瘤细胞系增殖方面优于阳性对照药物顺铂。酸浆苦素化合物表现出潜在的抗肿瘤活性，被认为值得在抗肿瘤药物开发和保健食品应用领域进一步研究。
