Castagliuolo Giusy, Porrello Antonella, Cerasola Maddalena, Bazan Giuseppe, Antonini Dario, Varcamonti Mario, Bruno Maurizio, Zanfardino Anna, Badalamenti Natale
Department of Biology, University of Naples Federico II, 80126 Naples, Italy.
Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), Università degli Studi di Palermo, Viale delle Scienze, ed. 17, 90128 Palermo, Italy.
Plants (Basel). 2025 Jul 18;14(14):2227. doi: 10.3390/plants14142227.
is a large genus of the Apiaceae family, comprising around forty-five accepted species, that has a worldwide distribution. Species of this genus have been reported to have several traditional medicinal uses, and some of them are also largely used as food and spices. Strobl. is an endemic species of Sicily growing in the montane environments of the Madonie and the Nebrodi Mountains. In this work, the essential oil of (EO), collected wild near Messina (Italy), was chemically and biologically investigated. The hydrodistilled essential oil (yield 0.15%), obtained from fresh aerial parts, was evaluated by GC-MS, and It was particularly rich in monoterpene hydrocarbons, with sabinene (33.6%), α-pinene (17.2%), -terpinene (9.8%), and α-terpinene (7.6%) as the main metabolites. EO, and its main constituents, have been tested to evaluate their biological properties. Given the current problem of antibiotic resistance, it is of great interest to identify alternative molecules that could counteract the its progression. Therefore, EO was tested against Gram-negative species, such as DH5α and PAOI, and Gram-positive species, such as ATCC6538P, AZ54, and MC155, showing notable antibacterial activity. The MIC for , the most sensitive strain, was 18 mg/mL, while the MIC for , the least sensitive strain, was 30 mg/mL. Moreover, interesting antibiofilm activity was observed against with a 55% inhibition. Its ability to form biofilms contributes to its persistence and resistance in clinical settings. These findings highlight the potential of EO as a source of bioactive compounds with promising antimicrobial and antibiofilm properties.
是伞形科的一个大属，包含约45个公认的物种，分布于世界各地。据报道，该属的物种有多种传统药用用途，其中一些也大量用作食物和香料。Strobl.是西西里岛的特有物种，生长在马多尼和内布罗德山脉的山区环境中。在这项工作中，对采自意大利墨西拿附近野外的（某种植物）精油进行了化学和生物学研究。通过水蒸馏法从新鲜地上部分获得的精油（产率0.15%），采用气相色谱 - 质谱联用仪进行了评估，其富含单萜烃类化合物，主要代谢产物为桧烯（33.6%）、α - 蒎烯（17.2%）、γ - 萜品烯（9.8%）和α - 萜品烯（7.6%）。对该精油及其主要成分进行了测试以评估它们的生物学特性。鉴于当前抗生素耐药性问题，识别能够对抗其发展的替代分子具有重大意义。因此，对该精油针对革兰氏阴性菌，如DH5α和PAOI，以及革兰氏阳性菌，如ATCC6538P、AZ54和MC155进行了测试，显示出显著的抗菌活性。对最敏感菌株的最低抑菌浓度为18毫克/毫升，而对最不敏感菌株的最低抑菌浓度为30毫克/毫升。此外，观察到对（某种菌）具有有趣的抗生物膜活性，抑制率为55%。其形成生物膜的能力有助于其在临床环境中的持续存在和耐药性。这些发现突出了该精油作为具有潜在抗菌和抗生物膜特性的生物活性化合物来源的潜力。
