Hernández-Triana Luis M, Sewgobind Sanam, Parekh Insiyah, Johnson Nicholas, Mansfield Karen L
Animal and Plant Health Agency, Addlestone, Surrey KT153NB, UK.
Viruses. 2025 Jun 20;17(7):869. doi: 10.3390/v17070869.
Japanese encephalitis virus (JEV) is a mosquito-borne orthoflavivirus and a major cause of human encephalitis throughout Asia, although it is currently not reported in Europe. To assess the potential impact of climate change, such as increased temperatures, and the potential for native to transmit JEV genotype I in the United Kingdom (UK), we have investigated vector competence at two different temperatures. f. were provided a bloodmeal containing JEV genotype I at 7.8 × 10 PFU/mL. Mosquitoes were maintained for 14 days at 21 °C or 25 °C, and rates of infection, dissemination, and transmission potential were assessed. There was no evidence for virus infection, dissemination, or potential for transmission at 21 °C. However, at 25 °C, virus infection was detected in 5 of 36 mosquitoes (13.9%). Of these, JEV disseminated to legs and wings in three specimens (3/5) and viral RNA was detected in saliva from one specimen (1/3). These data indicate that at elevated temperatures of 25 °C, UK f. could transmit JEV genotype 1.
日本脑炎病毒（JEV）是一种由蚊子传播的正黄病毒，是亚洲地区人类脑炎的主要病因，不过目前在欧洲尚无相关报道。为评估气候变化（如气温升高）的潜在影响以及英国本土蚊子传播JEV基因型I的可能性，我们在两种不同温度下研究了蚊子的媒介能力。给蚊子提供含有浓度为7.8×10 PFU/mL的JEV基因型I的血餐。将蚊子分别在21°C或25°C下饲养14天，并评估感染率、传播率和传播潜能。在21°C时未发现病毒感染、传播或传播潜能的证据。然而，在25°C时，36只蚊子中有5只（13.9%）检测到病毒感染。其中，3只标本（3/5）的JEV传播到了腿部和翅膀，1只标本（1/3）的唾液中检测到了病毒RNA。这些数据表明，在25°C的高温下，英国的某种蚊子可能传播JEV基因型1。 （注：原文中“f.”指代不明，翻译时保留原样）
