Cui Jia-Zhen, Xiong Xiang-Hua, Wang Qing-Yang, Dong Hao-Long, Liu Gang, Chen Hui-Peng
Academy of Military Medical Sciences, Beijing 100850, China.
Vaccines (Basel). 2025 Jul 21;13(7):769. doi: 10.3390/vaccines13070769.
Pathogenic flaviviruses are predominantly the pathogens of emerging and re-emerging infectious diseases, which have caused multiple public health emergencies globally and pose a serious threat to human health and social development. Although significant achievements have been made in vaccine research, issues such as limited protective effects and virulence reversion persist, making the development of novel vaccines against pathogenic flaviviruses a current research hotspot and challenge. ISFVs have recently attracted attention due to their high homology with pathogenic flaviviruses and unique inability to replicate in mammalian hosts. Multiple vaccine candidate strains constructed using ISFVs as scaffolds have demonstrated excellent safety and efficacy. This review summarizes the biological characteristics, host restriction factors, current applications in vaccine development, and challenges faced by ISFVs, providing a reference for future research on pathogenic flavivirus vaccines.
致病性黄病毒主要是新出现和再次出现的传染病病原体，已在全球范围内引发多起突发公共卫生事件，对人类健康和社会发展构成严重威胁。尽管疫苗研究取得了显著成就，但仍存在保护效果有限和毒力回复等问题，使得开发针对致病性黄病毒的新型疫苗成为当前的研究热点和挑战。昆虫特异性黄病毒（ISFVs）最近因其与致病性黄病毒的高度同源性以及在哺乳动物宿主中独特的无法复制的特性而受到关注。使用ISFVs作为支架构建的多种候选疫苗株已显示出优异的安全性和有效性。本综述总结了ISFVs的生物学特性、宿主限制因素、目前在疫苗开发中的应用以及面临的挑战，为未来致病性黄病毒疫苗的研究提供参考。
