Wang Tian, Zhang Qi, Wang Li, Wang Jie, Zhao Keqing, Song Xinmao
Department of Radiation Oncology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Department of Ophthalmology, Shanghai Public Health Clinical Center, Shanghai, China.
Sci Prog. 2025 Jul-Sep;108(3):368504251364321. doi: 10.1177/00368504251364321. Epub 2025 Jul 29.
ObjectiveSinonasal squamous cell carcinoma usually presents at an advanced stage at the time of diagnosis, and there is still a lack of indicators to predict the prognosis of sinonasal squamous cell carcinoma patients. We aim to investigate whether the peripheral blood ratios may be good options for predicting the progression in patients with sinonasal squamous cell carcinoma.MethodsWe performed a retrospective analysis of 198 patients with sinonasal squamous cell carcinoma between January 2010 and December 2022. The systemic inflammatory response index, platelet/lymphocyte ratio, neutrophil/lymphocyte ratio, and lymphocyte/monocyte ratio were calculated. We examined the predictive value for the prognosis of sinonasal squamous cell carcinoma patients.ResultsThe systemic inflammatory response index (1.21 vs. 0.79, < 0.001), lymphocyte/monocyte ratio (3.51 vs. 5.01, < 0.001), neutrophil/lymphocyte ratio (2.83 vs. 2.02, < 0.001), and platelet/lymphocyte ratio (136.70 vs. 113.84, = 0.0042) values were significantly different between T4 stage and T1-3 stage. Univariate analysis showed that using appropriate threshold values, systemic inflammatory response index (0.5), platelet/lymphocyte ratio (127.4), lymphocyte/monocyte ratio (4.9), and neutrophil/lymphocyte ratio (2.6) predicted overall survival, progression-free survival, and distant metastasis-free survival. Multivariate Cox regression showed that high lymphocyte/monocyte ratio was associated with poor prognosis.ConclusionsThe values of neutrophil/lymphocyte ratio, systemic inflammatory response index, lymphocyte/monocyte ratio, and platelet/lymphocyte ratio can be used as parameters for the prognosis of sinonasal squamous cell carcinoma. In sinonasal squamous cell carcinoma patients, lymphocyte/monocyte ratio is a sensitive factor in predicting overall survival and distant metastasis-free survival.
目的
鼻窦鳞状细胞癌通常在诊断时已处于晚期，目前仍缺乏预测鼻窦鳞状细胞癌患者预后的指标。我们旨在研究外周血比值是否可能是预测鼻窦鳞状细胞癌患者病情进展的良好指标。
方法
我们对2010年1月至2022年12月期间的198例鼻窦鳞状细胞癌患者进行了回顾性分析。计算全身炎症反应指数、血小板/淋巴细胞比值、中性粒细胞/淋巴细胞比值和淋巴细胞/单核细胞比值。我们研究了这些指标对鼻窦鳞状细胞癌患者预后的预测价值。
结果
T4期与T1 - 3期患者的全身炎症反应指数（1.21对0.79，<0.001）、淋巴细胞/单核细胞比值（3.51对5.01，<0.001）、中性粒细胞/淋巴细胞比值（2.83对2.02，<0.001）和血小板/淋巴细胞比值（136.70对113.84，=0.0042）差异有统计学意义。单因素分析显示，使用适当的阈值时，全身炎症反应指数（0.5）、血小板/淋巴细胞比值（127.4）、淋巴细胞/单核细胞比值（4.9）和中性粒细胞/淋巴细胞比值（2.6）可预测总生存期、无进展生存期和无远处转移生存期。多因素Cox回归分析显示，高淋巴细胞/单核细胞比值与预后不良相关。
结论
中性粒细胞/淋巴细胞比值、全身炎症反应指数、淋巴细胞/单核细胞比值和血小板/淋巴细胞比值可作为鼻窦鳞状细胞癌预后的参数。在鼻窦鳞状细胞癌患者中，淋巴细胞/单核细胞比值是预测总生存期和无远处转移生存期的敏感因素。
