Prognostic impact of peripheral blood ratio in sinonasal squamous cell carcinoma.

ObjectiveSinonasal squamous cell carcinoma usually presents at an advanced stage at the time of diagnosis, and there is still a lack of indicators to predict the prognosis of sinonasal squamous cell carcinoma patients. We aim to investigate whether the peripheral blood ratios may be good options for predicting the progression in patients with sinonasal squamous cell carcinoma.MethodsWe performed a retrospective analysis of 198 patients with sinonasal squamous cell carcinoma between January 2010 and December 2022. The systemic inflammatory response index, platelet/lymphocyte ratio, neutrophil/lymphocyte ratio, and lymphocyte/monocyte ratio were calculated. We examined the predictive value for the prognosis of sinonasal squamous cell carcinoma patients.ResultsThe systemic inflammatory response index (1.21 vs. 0.79,  < 0.001), lymphocyte/monocyte ratio (3.51 vs. 5.01,  < 0.001), neutrophil/lymphocyte ratio (2.83 vs. 2.02,  < 0.001), and platelet/lymphocyte ratio (136.70 vs. 113.84,  = 0.0042) values were significantly different between T4 stage and T1-3 stage. Univariate analysis showed that using appropriate threshold values, systemic inflammatory response index (0.5), platelet/lymphocyte ratio (127.4), lymphocyte/monocyte ratio (4.9), and neutrophil/lymphocyte ratio (2.6) predicted overall survival, progression-free survival, and distant metastasis-free survival. Multivariate Cox regression showed that high lymphocyte/monocyte ratio was associated with poor prognosis.ConclusionsThe values of neutrophil/lymphocyte ratio, systemic inflammatory response index, lymphocyte/monocyte ratio, and platelet/lymphocyte ratio can be used as parameters for the prognosis of sinonasal squamous cell carcinoma. In sinonasal squamous cell carcinoma patients, lymphocyte/monocyte ratio is a sensitive factor in predicting overall survival and distant metastasis-free survival.