Wang Kui, Wu Zuoyuan, Shen Xiangnan, Wang Yanjun, Mu Chenglin
Kui Wang, Department of Orthopedics and Traumatology, Hebei Province Hospital of Chinese Medicine, Shijiazhuang 050000, Hebei, China.
Zuoyuan Wu, Department of Orthopedics and Traumatology, Hebei Province Hospital of Chinese Medicine, Shijiazhuang 050000, Hebei, China.
Pak J Med Sci. 2025 Jul;41(7):2036-2040. doi: 10.12669/pjms.41.7.10724.
To investigate the clinical efficacy of traditional Chinese medicine (TCM) compound in the treatment of knee osteoarthritis (KOA) and its impact on inflammatory cytokine levels.
A retrospective analysis was conducted on the medical records of 80 KOA patients admitted to Hebei Province Hospital of Chinese Medicine from January 2021 to January 2023. The patients were divided into an observation group and a control group based on different treatment methods (n=40 each group). The visual analogue scale (VAS) was adopted to assess patients' pain level, and the Lysholm score was used to evaluate knee joint function, and the clinical outcomes of the two groups were compared.
After treatment, both groups exhibited a significant decrease in VAS scores, with the observation group showing a more substantial reduction(P<0.05). The Lysholm scores of both groups were significantly higher after treatment than before treatment (P<0.05). Serum levels of CRP, IL-6, and TNF-α decreased significantly in both groups after treatment, with the observation group showing a more pronounced reduction (P<0.05). The ADL scores for both advanced and basic abilities improved significantly post-treatment in both groups, with the observation group demonstrating a statistically significant greater improvement (P<0.05). The treatment efficacy for the observation group was 92.50%, which was significantly higher than the control group's rate of 77.50% (χ²=4.114, P<0.05).
Traditional Chinese Medicine(TCM) compound therapy for KOA can significantly alleviate patients' pain, reduce the expression of inflammatory factors in serum, enhance knee joint function, and improve patients' quality of life.
探讨中药复方治疗膝关节骨关节炎（KOA）的临床疗效及其对炎症细胞因子水平的影响。
对2021年1月至2023年1月河北省中医院收治的80例KOA患者的病历进行回顾性分析。根据不同治疗方法将患者分为观察组和对照组（每组n = 40）。采用视觉模拟评分法（VAS）评估患者疼痛程度，采用Lysholm评分评估膝关节功能，比较两组临床疗效。
治疗后，两组VAS评分均显著降低，观察组降低更明显（P < 0.05）。两组治疗后Lysholm评分均显著高于治疗前（P < 0.05）。两组治疗后血清CRP、IL - 6和TNF - α水平均显著降低，观察组降低更显著（P < 0.05）。两组治疗后高级和基本能力的ADL评分均显著改善，观察组改善更具统计学意义（P < 0.05）。观察组治疗有效率为92.50%，显著高于对照组的77.50%（χ² = 4.114，P < 0.05）。
中药复方治疗KOA可显著减轻患者疼痛，降低血清炎症因子表达，增强膝关节功能，提高患者生活质量。
