Xing Lili, Cheng Mao, Wang Shulei, Jiang Jide, Li Ting, Zhang Xinyu, Yang Jian, Tian Yunlong, Liu Wenjuan
Bacteriological Disease Laboratory, Yantai Center for Disease Control and Prevention, Yantai, Shandong, China.
Food Inspection and Testing Technology Teaching and Research Office, Yantai Engineering and Technology College, Yantai, Shandong, China.
Front Microbiol. 2025 Jul 15;16:1636622. doi: 10.3389/fmicb.2025.1636622. eCollection 2025.
Methicillin-resistant (MRSA) is distributed all over the world and can easily colonize food animals, which can be transmitted through the food chain, posing a threat to food safety and public health. This study aimed to elucidate the global prevalence of MRSA contamination in meat and meat products via systematic review and meta-analysis.
A comprehensive retrieval was conducted in PubMed, Embase, Web of Science, and the Cochrane Library to identify eligible studies published up to December 10, 2024. Epidemiological data and study characteristics were extracted. Meta-analysis was made using a random-effects model in R software. Subgroup analyses were carried out by meat type, geographical region, and study period. Sensitivity analyses were launched to test the robustness of results, and the trim-and-fill method was applied to assess the potential impact of publication bias.
The pooled prevalence of MRSA contamination in meat and meat products was 3.72% (95% CI: 2.75-5.02%). The prevalence was 4.46% (95%CI: 2.82-6.98%) in raw poulty meat, 3.86% (95% CI: 2.58-5.74%) in raw livestock meat, and 2.84% (95%CI: 0.55-13.32%) in processed meat products. The Eastern Mediterranean region had the highest MRSA prevalence (9.13%; 95% CI: 4.28-18.44%), while North America reported the lowest (1.89%; 95% CI: 1.30-2.74%). Since 2015, the global prevalence of MRSA was 8.33% (95% CI: 5.29-12.86%). The adjusted pooled prevalence increased to 14.04% (95% CI: 10.38-18.73%) after applying the trim-and-fill method.
The presence of MRSA in meat and meat products represents a public health concern. Enhanced surveillance efforts should prioritize raw livestock and poultry meat, particularly in the Eastern Mediterranean and Southeast Asia, to mitigate MRSA contamination in the food supply.
CRD420251009933, https://www.crd.york.ac.uk/PROSPERO/view/CRD420251009933.
耐甲氧西林金黄色葡萄球菌（MRSA）在全球范围内广泛分布，且极易在食用动物中定植，可通过食物链传播，对食品安全和公众健康构成威胁。本研究旨在通过系统评价和荟萃分析阐明肉类及肉类产品中MRSA污染的全球流行情况。
在PubMed、Embase、Web of Science和Cochrane图书馆进行全面检索，以识别截至2024年12月10日发表的符合条件的研究。提取流行病学数据和研究特征。使用R软件中的随机效应模型进行荟萃分析。按肉类类型、地理区域和研究时期进行亚组分析。开展敏感性分析以检验结果的稳健性，并应用修剪填充法评估发表偏倚的潜在影响。
肉类及肉类产品中MRSA污染的合并患病率为3.72%（95%CI：2.75 - 5.02%）。生禽肉中的患病率为4.46%（95%CI：2.82 - 6.98%），生畜肉中的患病率为3.86%（95%CI：2.58 - 5.74%），加工肉类产品中的患病率为2.84%（95%CI：0.55 - 13.32%）。东地中海地区的MRSA患病率最高（9.13%；95%CI：4.28 - 18.44%），而北美地区的患病率最低（1.89%；95%CI：1.30 - 2.74%）。自2015年以来，全球MRSA患病率为8.33%（95%CI：5.29 - 12.86%）。应用修剪填充法后，调整后的合并患病率增至14.04%（95%CI：10.38 - 18.73%）。
肉类及肉类产品中存在MRSA是一个公共卫生问题。应加强监测力度，将重点放在生畜肉和禽肉上，特别是在东地中海和东南亚地区，以减轻食品供应中的MRSA污染。
CRD420251009933，https://www.crd.york.ac.uk/PROSPERO/view/CRD420251009933 。
