Chen Rui, Yang Zhiqi, Chen Yining, Wang Jinjie, Wang Yuhang, Wei Liqi, Yu Pengcheng, Zhang Mengyuan, Yan Yan, Yang Shuo, Wang Lili, Cheng Yan
Jilin Provincial Key Laboratory of Human Health Status Identification and Function Enhancement, School of Materials Science and Engineering, Changchun University, Changchun, 130022, China.
Engineering Research Center of the Chinese Ministry of Education for Bioreactor and Pharmaceutical Development, College of Life Science, Jilin Agricultural University, Changchun, 130118, China.
Mater Today Bio. 2025 Jul 19;34:102118. doi: 10.1016/j.mtbio.2025.102118. eCollection 2025 Oct.
Hypoxia and electron-hole recombination are two obstacles limiting sonodynamic therapeutic efficacy against cancer. Herein, bismuth sulfide (BiS)-titania (TiO) heterostructure is designed based on the excellent photothermal property of BiS, which could improve intratumor oxygen content through increasing blood flow with the help of near infrared light. BiS-TiO heterostructure nanoparticles (NPs) present similar photothermal performance to BiS NPs, while BiS-TiO NPs show higher reactive oxygen species (ROS) generating ability than BiS NPs under ultrasonic irradiation. assessments proved that BiS-TiO NPs could produce heat and ROS to damage mitochondrial, leading to cell death due to their synergetic photothermal and sonodynamic performances. After being administrated into tumor, BiS-TiO NPs can effectively improve oxygen content at 8 h post 808 nm laser irradiation. The tumor growth inhibition rate of BiS-TiO NPs with 808 nm laser or ultrasound irradiation is 77.49 ± 3.96 % and 63.64 ± 2.2.7 %, respectively, while it reaches up 88.82 ± 3.98 % when 808 nm laser and ultrasound are applied in sequence, proving the photothermal amplified sonodynamic therapeutic efficacy against hypoxic tumor. As a result, the design of BiS-TiO heterostructure NPs realizes photothermal amplified sonodynamic therapy, providing a potential strategy for treating hypoxic tumors.
缺氧和电子-空穴复合是限制癌症声动力治疗效果的两个障碍。在此，基于硫化铋（BiS）优异的光热性能设计了硫化铋（BiS）-二氧化钛（TiO）异质结构，其可借助近红外光增加血流量来提高肿瘤内氧含量。BiS-TiO异质结构纳米颗粒（NPs）呈现出与BiS NPs相似的光热性能，而BiS-TiO NPs在超声辐照下比BiS NPs表现出更高的活性氧（ROS）生成能力。评估证明，BiS-TiO NPs可产生热量和ROS来损伤线粒体，因其光热和声动力协同性能导致细胞死亡。将BiS-TiO NPs注入肿瘤后，在808 nm激光照射8小时后可有效提高氧含量。808 nm激光或超声辐照下BiS-TiO NPs的肿瘤生长抑制率分别为77.49±3.96%和63.64±2.27%，而当依次应用808 nm激光和超声时，肿瘤生长抑制率高达88.82±3.98%，证明了对缺氧肿瘤的光热增强声动力治疗效果。因此，BiS-TiO异质结构NPs的设计实现了光热增强声动力治疗，为治疗缺氧肿瘤提供了一种潜在策略。
