Deldar A, Lewis H, Weiss L
Anat Rec. 1985 Oct;213(2):187-201. doi: 10.1002/ar.1092130211.
Hematopoietic bone marrow in the dog is enclosed by a nearly complete and rather complex layer of endosteum, consisting of a diverse group of cells collectively called bone lining cells (BLC). Cell types comprising BLC include osteoblasts and osteoclasts, and other cell types, among which are elongated, flat cells with a spindle-shaped nucleus, and small cytoplasmic vesicles. The composition and thickness of the layer of BLC varies along the perimeter of the marrow. The layer may be simple or stratified. Occasionally a zone of tightly packed regularly arranged collagenous fibers lies between the bone lining cells and bone. Hematopoiesis, particularly neutrophilic, often occurs in the bone marrow next to the BLC. Cytoplasmic processes of BLC occasionally extend into the hematopoietic spaces and stromal cells in the hematopoietic compartment may extend processes to the layer of BLC. Occasionally cells of the BLC are similar in appearance to stromal cells within the marrow. Our observations together with the experimental findings of others (that fibroblastic stromal cells contribute to the hematopoietic inductive microenvironment, that hematopoietic stem cells are concentrated subosteally, that cells responsible for regeneration of the marrow stroma are derived from the endosteal layer, and that high concentrations of hematopoietic colony-stimulating factors are produced there) indicate that the hematopoietic capacities of bone marrow may be regulated by BLC.
犬的造血骨髓被一层几乎完整且相当复杂的骨内膜所包围，骨内膜由一组统称为骨衬细胞（BLC）的不同细胞组成。构成BLC的细胞类型包括成骨细胞和破骨细胞，以及其他细胞类型，其中有具有纺锤形细胞核的细长扁平细胞和小的细胞质小泡。BLC层的组成和厚度沿骨髓周边变化。该层可能是单层的或分层的。偶尔，在骨衬细胞和骨之间会有一层紧密排列的规则排列的胶原纤维。造血，尤其是嗜中性粒细胞造血，常常发生在靠近BLC的骨髓中。BLC的细胞质突起偶尔会延伸到造血空间，造血区室中的基质细胞可能会将突起延伸到BLC层。偶尔，BLC的细胞在外观上与骨髓内的基质细胞相似。我们的观察结果以及其他人的实验发现（成纤维细胞基质细胞有助于造血诱导微环境，造血干细胞集中在骨膜下，负责骨髓基质再生的细胞来源于骨内膜层，并且在那里产生高浓度的造血集落刺激因子）表明，骨髓的造血能力可能受BLC调节。
