• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

基于MAPK信号通路探讨藤黄菌素抑制肺癌NCI-H1299细胞增殖的机制研究 （原英文文本似乎不完整，“inhibiting the of”这里应该有缺失内容，我按照合理推测进行了补充翻译）

Study on the mechanism of gracillin inhibiting the of lung cancer NCI-H1299 cells based on MAPK signaling pathway.

作者信息

Xiao Bang, Zhang Minhong, Liu Hai, Cui Aiping, Tian Yihe, Tang Fosheng, Liao Shichen, Li Mingchun, Huang Hao, Peng Weijie, Yang Jianqiong

机构信息

The Clinical Medicine Research Center of the First Clinical Medical College, Gannan Medical University, Ganzhou, China.

School of Rehabilitation Medicine, Gannan Medical University, Ganzhou, China.

出版信息

J Cancer. 2025 Jul 1;16(10):3048-3064. doi: 10.7150/jca.113694. eCollection 2025.

DOI:10.7150/jca.113694
PMID:40740238
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12305431/
Abstract

In this study, we investigated the potential of gracillin, a steroidal saponin compound, as an anticancer agent against non-small cell lung cancer (NSCLC) and explored its impact on autophagy mechanisms. Gracillin significantly inhibited NCI-H1299 cell proliferation and induced autophagic cell death. Mechanistically, gracillin activated the MAPK signaling pathway, evidenced by increased p-ERK and decreased p-JNK levels, suggesting their roles in mediating autophagy induction. Additionally, gracillin upregulated WIPI1 expression, a key autophagy-related protein potentially downstream of the ERK pathway. Evaluation in a xenograft mouse model demonstrated robust anticancer efficacy of gracillin with no significant adverse effects observed. These findings highlight gracillin as a promising candidate for NSCLC therapy, leveraging its ability to induce autophagy through MAPK pathway modulation. Our study provides valuable insights into the therapeutic potential of gracillin and supports its further development as a safe and effective treatment option for NSCLC.

摘要

在本研究中，我们调查了甾体皂苷化合物格拉西丁作为一种抗非小细胞肺癌（NSCLC）抗癌剂的潜力，并探讨了其对自噬机制的影响。格拉西丁显著抑制NCI-H1299细胞增殖并诱导自噬性细胞死亡。从机制上讲，格拉西丁激活了MAPK信号通路，表现为p-ERK水平升高和p-JNK水平降低，表明它们在介导自噬诱导中发挥作用。此外，格拉西丁上调了WIPI1的表达，WIPI1是一种潜在位于ERK通路下游的关键自噬相关蛋白。在异种移植小鼠模型中的评估表明，格拉西丁具有强大的抗癌功效，未观察到明显的不良反应。这些发现突出了格拉西丁作为NSCLC治疗有前景的候选药物，利用其通过调节MAPK通路诱导自噬的能力。我们的研究为格拉西丁的治疗潜力提供了有价值的见解，并支持其作为NSCLC安全有效的治疗选择进一步开发。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f009/12305431/df61bb80daff/jcav16p3048g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f009/12305431/bee1e181641c/jcav16p3048g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f009/12305431/c8a997d19901/jcav16p3048g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f009/12305431/00a8b8a9ee9b/jcav16p3048g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f009/12305431/de1d0ee07e09/jcav16p3048g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f009/12305431/a6a4db6a7f14/jcav16p3048g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f009/12305431/39a36509dd83/jcav16p3048g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f009/12305431/45973940f9b9/jcav16p3048g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f009/12305431/2edc15d576ea/jcav16p3048g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f009/12305431/f74b74a2209e/jcav16p3048g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f009/12305431/43b390681f38/jcav16p3048g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f009/12305431/bfda1bf31a1d/jcav16p3048g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f009/12305431/96c396f5b148/jcav16p3048g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f009/12305431/d00d01d8a39a/jcav16p3048g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f009/12305431/df61bb80daff/jcav16p3048g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f009/12305431/bee1e181641c/jcav16p3048g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f009/12305431/c8a997d19901/jcav16p3048g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f009/12305431/00a8b8a9ee9b/jcav16p3048g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f009/12305431/de1d0ee07e09/jcav16p3048g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f009/12305431/a6a4db6a7f14/jcav16p3048g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f009/12305431/39a36509dd83/jcav16p3048g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f009/12305431/45973940f9b9/jcav16p3048g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f009/12305431/2edc15d576ea/jcav16p3048g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f009/12305431/f74b74a2209e/jcav16p3048g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f009/12305431/43b390681f38/jcav16p3048g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f009/12305431/bfda1bf31a1d/jcav16p3048g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f009/12305431/96c396f5b148/jcav16p3048g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f009/12305431/d00d01d8a39a/jcav16p3048g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f009/12305431/df61bb80daff/jcav16p3048g014.jpg

相似文献

1
Study on the mechanism of gracillin inhibiting the of lung cancer NCI-H1299 cells based on MAPK signaling pathway.基于MAPK信号通路探讨藤黄菌素抑制肺癌NCI-H1299细胞增殖的机制研究 （原英文文本似乎不完整，“inhibiting the of”这里应该有缺失内容，我按照合理推测进行了补充翻译）
J Cancer. 2025 Jul 1;16(10):3048-3064. doi: 10.7150/jca.113694. eCollection 2025.
2
Gracillin suppresses cancer progression through inducing Merlin/LATS protein-protein interaction and activating Hippo signaling pathway.格拉西林通过诱导Merlin/LATS蛋白-蛋白相互作用和激活Hippo信号通路来抑制癌症进展。
Acta Pharmacol Sin. 2025 Mar 7. doi: 10.1038/s41401-025-01514-w.
3
Tricin selectively combats KRAS-mutant non-small cell lung cancer by inhibiting the PDGF-BB-induced SRC/MAPK/AP-1/PD-L1 signaling pathway and potentiating the antitumor effect of an anti-PD-1 antibody.小麦黄素通过抑制血小板衍生生长因子-BB（PDGF-BB）诱导的SRC/丝裂原活化蛋白激酶（MAPK）/活化蛋白-1（AP-1）/程序性死亡配体1（PD-L1）信号通路，选择性对抗KRAS突变的非小细胞肺癌，并增强抗程序性死亡蛋白1（PD-1）抗体的抗肿瘤作用。
Front Pharmacol. 2025 Jun 17;16:1594213. doi: 10.3389/fphar.2025.1594213. eCollection 2025.
4
M1 Macrophage-Derived TNF-α Promotes Pancreatic Cancer Ferroptosis Via p38 MAPK-ACSL4 Pathway.M1型巨噬细胞衍生的肿瘤坏死因子-α通过p38丝裂原活化蛋白激酶-长链脂酰辅酶A合成酶4途径促进胰腺癌铁死亡。
Curr Mol Med. 2025 Jul 10. doi: 10.2174/0115665240374551250630075409.
5
Achillea fragrantissima (Forssk.) Sch. Bip. essential oil inhibits the growth of pancreatic cancer cells via induction of necrosis, sub-G1 arrest, modulation of β-catenin/ERK signalling pathways and p38α MAPK, CDK2, EGFR inhibition.香叶蓍（Achillea fragrantissima (Forssk.) Sch. Bip.）精油通过诱导坏死、亚G1期阻滞、调节β-连环蛋白/ERK信号通路以及抑制p38α丝裂原活化蛋白激酶、细胞周期蛋白依赖性激酶2（CDK2）和表皮生长因子受体（EGFR）来抑制胰腺癌细胞的生长。
J Ethnopharmacol. 2025 Jun 24;352:120201. doi: 10.1016/j.jep.2025.120201.
6
Integrin αVβ1-activated PYK2 promotes the progression of non-small-cell lung cancer via the STAT3-VGF axis.整合素 αVβ1 激活的 PYK2 通过 STAT3-VGF 轴促进非小细胞肺癌的进展。
Cell Commun Signal. 2024 Jun 6;22(1):313. doi: 10.1186/s12964-024-01639-1.
7
Caveolin-1 inhibits the proliferation and invasion of lung adenocarcinoma via EGFR degradation.小窝蛋白-1通过表皮生长因子受体（EGFR）降解抑制肺腺癌的增殖和侵袭。
Sci Rep. 2025 Jul 1;15(1):21654. doi: 10.1038/s41598-025-05259-8.
8
Resveratrol in oral cancer: a systematic review of preclinical studies on its anticancer mechanisms and therapeutic potential.白藜芦醇在口腔癌中的应用：对其抗癌机制和治疗潜力的临床前研究的系统综述
Med Oncol. 2025 Jul 13;42(8):329. doi: 10.1007/s12032-025-02903-1.
9
Autophagy-related CMTM6 promotes glioblastoma progression by activating Wnt/β-catenin pathway and acts as an onco-immunological biomarker.自噬相关的CMTM6 通过激活 Wnt/β-catenin 通路促进胶质母细胞瘤的进展，并作为一种癌免疫生物学标志物。
J Gene Med. 2024 May;26(5):e3685. doi: 10.1002/jgm.3685.
10
VT204: A Potential Small Molecule Inhibitor Targeting KRASG12C Mutation for Therapeutic Intervention in Non-Small Cell Lung Cancer.VT204：一种针对 KRASG12C 突变的潜在小分子抑制剂，可用于治疗非小细胞肺癌。
Technol Cancer Res Treat. 2024 Jan-Dec;23:15330338241264853. doi: 10.1177/15330338241264853.

本文引用的文献

1
[Cancer incidence and mortality in China, 2022].[2022年中国癌症发病率和死亡率]
Zhonghua Zhong Liu Za Zhi. 2024 Mar 23;46(3):221-231. doi: 10.3760/cma.j.cn112152-20240119-00035.
2
Autophagy: Regulator of cell death.自噬：细胞死亡的调控者。
Cell Death Dis. 2023 Oct 4;14(10):648. doi: 10.1038/s41419-023-06154-8.
3
Immune checkpoint therapy for solid tumours: clinical dilemmas and future trends.实体瘤的免疫检查点治疗：临床困境与未来趋势。
Signal Transduct Target Ther. 2023 Aug 28;8(1):320. doi: 10.1038/s41392-023-01522-4.
4
The ABL-MYC axis controls WIPI1-enhanced autophagy in lifespan extension.ABL-MYC 轴控制 WIPI1 增强的自噬以延长寿命。
Commun Biol. 2023 Aug 24;6(1):872. doi: 10.1038/s42003-023-05236-9.
5
Autophagy Regulators in Cancer.自噬调控因子与癌症
Int J Mol Sci. 2023 Jun 30;24(13):10944. doi: 10.3390/ijms241310944.
6
Gracillin relieves pulmonary fibrosis by suppressing the STAT3 axis.格雷斯林通过抑制 STAT3 轴缓解肺纤维化。
J Ethnopharmacol. 2023 Nov 15;316:116704. doi: 10.1016/j.jep.2023.116704. Epub 2023 May 29.
7
Gracillin exerts anti-melanoma effects in vitro and in vivo: role of DNA damage, apoptosis and autophagy.藜芦酰精氨酸在体外和体内发挥抗黑色素瘤作用：与 DNA 损伤、细胞凋亡和自噬的关系。
Phytomedicine. 2023 Jan;108:154526. doi: 10.1016/j.phymed.2022.154526. Epub 2022 Oct 27.
8
EIF3C Promotes Lung Cancer Tumorigenesis by Regulating the APP/HSPA1A/LMNB1 Axis.EIF3C 通过调节 APP/HSPA1A/LMNB1 轴促进肺癌肿瘤发生。
Dis Markers. 2022 Sep 14;2022:9464094. doi: 10.1155/2022/9464094. eCollection 2022.
9
Curcumin Induces Apoptosis of Chemoresistant Lung Cancer Cells via ROS-Regulated p38 MAPK Phosphorylation.姜黄素通过 ROS 调控的 p38 MAPK 磷酸化诱导耐药肺癌细胞凋亡。
Int J Mol Sci. 2022 Jul 26;23(15):8248. doi: 10.3390/ijms23158248.
10
Physiological functions and roles in cancer of the proliferation marker Ki-67.增殖标志物 Ki-67 的生理功能及其在癌症中的作用。
J Cell Sci. 2022 Jun 1;135(11). doi: 10.1242/jcs.258932. Epub 2022 Jun 8.