Nasiri Danial, Maragkou Theoni, Raabe Andreas, Krähenbühl Anna Katharina, Wagner Franca
Department of Neurosurgery, Inselspital, 3010, Bern, Switzerland.
Department of Pathology, Inselspital, 3010, Bern, Switzerland.
BJR Case Rep. 2025 Jul 17;11(4):uaaf037. doi: 10.1093/bjrcr/uaaf037. eCollection 2025 Jul.
Primary central nervous system (CNS) mucosa-associated lymphoid tissue (MALT) lymphoma is a rare condition frequently mistaken for meningioma. Since these conditions require distinct treatment approaches, recognizing their imaging characteristics is essential for accurate clinical decision-making. A 69-year-old woman presented with headaches and forehead swelling, prompting MRI of the CNS. Suspecting an intracranial meningioma, the tumour board recommended surgical resection. However, histopathological analysis identified the lesion as a primary CNS MALT lymphoma. Follow-up revealed secondary cutaneous tumour infiltration, leading to a delay in adjuvant radiotherapy. Understanding the differential diagnoses of meningioma is critical for neuroradiologists and neurosurgeons to ensure appropriate treatment planning. This case highlights a misdiagnosis of meningioma that was ultimately identified as a primary CNS MALT lymphoma, emphasizing key imaging and clinical characteristics essential for distinguishing between the most important differential diagnoses of primary CNS MALT lymphoma.
原发性中枢神经系统（CNS）黏膜相关淋巴组织（MALT）淋巴瘤是一种罕见疾病，常被误诊为脑膜瘤。由于这些疾病需要不同的治疗方法，识别它们的影像学特征对于准确的临床决策至关重要。一名69岁女性因头痛和前额肿胀就诊，接受了中枢神经系统MRI检查。怀疑为颅内脑膜瘤，肿瘤委员会建议手术切除。然而，组织病理学分析确定该病变为原发性中枢神经系统MALT淋巴瘤。随访发现继发性皮肤肿瘤浸润，导致辅助放疗延迟。了解脑膜瘤的鉴别诊断对于神经放射科医生和神经外科医生确保适当的治疗计划至关重要。本病例突出了一例最初被误诊为脑膜瘤，最终被确诊为原发性中枢神经系统MALT淋巴瘤的病例，强调了区分原发性中枢神经系统MALT淋巴瘤最重要鉴别诊断所需的关键影像学和临床特征。
