Wang Qian, Tan Shiyan, Fu Xi, He Jiawei, Ma Qiong, You Fengming, You Liting, Ren Yifeng
Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Front Med (Lausanne). 2025 Jul 16;12:1611304. doi: 10.3389/fmed.2025.1611304. eCollection 2025.
Lung organoids have emerged as a promising tool for studying lung development, function, and disease pathology. The present study aimed to analyze the current status and development trends of lung organoid research over the past years, present visual representations, and provide references for future research directions using bibliometric analysis.
Information on articles on lung organoids extracted from the Web of Science Core Collection, such as year of publication, journal, country, institution, author, and keywords, was analyzed. R, VOSviewer, and SCImago Graphica were used to visualize publication trends, co-authorship analysis, co-occurrence analysis, and hotspot evolution.
The number of global publications has increased from 1 in 2011 to 929 in 2024. The Nature produced the highest number of citations (2,675 citations). The United States (8,155 citations and 281 publications), University Medical Center Utrecht (2083 citations and 11 publications), and Clevers H (2,711 citations and 21 publications) were the most influential countries, institutions, and authors, respectively. Co-occurrence cluster analysis of the top 54 keywords formed four clusters: (1) idiopathic pulmonary fibrosis, (2) lung cancer, (3) cystic fibrosis, (4) COVID-19.
Overall, research on lung organoids continues to increase. The United States of America and the Netherlands dominated global studies. The analysis of pulmonary fibrosis, lung cancer and COVID-19 occupied a prominent position of research in this area. The research hotspots for lung organoids are disease model and microphysiological systems. Standardization, accurate disease modeling, and ethics and safety remain pressing challenges that need to be addressed in this field.
肺类器官已成为研究肺发育、功能和疾病病理学的一种有前景的工具。本研究旨在通过文献计量分析来分析过去几年肺类器官研究的现状和发展趋势，呈现可视化表征，并为未来的研究方向提供参考。
对从科学网核心合集提取的有关肺类器官的文章信息进行分析，这些信息包括发表年份、期刊、国家、机构、作者和关键词等。使用R、VOSviewer和SCImago Graphica来可视化发表趋势、共同作者分析、共现分析和热点演变。
全球发表的文章数量已从2011年的1篇增加到2024年的929篇。《自然》杂志的被引次数最高（2675次被引）。美国（8155次被引和281篇发表文章）、乌得勒支大学医学中心（2083次被引和11篇发表文章）以及克莱弗斯·H（2711次被引和21篇发表文章）分别是最具影响力的国家、机构和作者。对前54个关键词进行共现聚类分析形成了四个聚类：（1）特发性肺纤维化，（2）肺癌，（3）囊性纤维化，（4）2019冠状病毒病。
总体而言，肺类器官的研究持续增加。美国和荷兰在全球研究中占主导地位。肺纤维化、肺癌和2019冠状病毒病的分析在该领域的研究中占据突出地位。肺类器官的研究热点是疾病模型和微生理系统。标准化、准确的疾病建模以及伦理和安全性仍然是该领域需要解决的紧迫挑战。
