Michel F B, Bousquet J, Greillier P, Robinet-Levy M, Coulomb Y
J Allergy Clin Immunol. 1980 Jun;65(6):422-30. doi: 10.1016/0091-6749(80)90234-1.
Total serum IgE levels were determined in 136 newborns and their mothers and in 54 of their fathers, using the paper radioimmunosorbent test (PRIST) technique. IgE specific antibodies for house dust (Dermatophagoides pteronyssinus), orchard grass, timothy grass, and cow's milk were measured with the radioallergosorbent test (RAST). One hundred thirty-three RAST assays were negative in newborns, and in three cases RAST for cow's milk was positive. Cord blood IgE ranged from 0 to 5.5 IU/ml (mean 0.32 +/- 0.54 IU/ml); levels were significantly (p less than 0.05) higher when maternal IgE was over 100 IU/ml and when mothers had received progesterone therapy during the pregnancy. Salbutamol administration or tobacco smoking during pregnancy did not influence newborn IgE. A clinical follow-up study was conducted in 83 infants for 9 mo. Nine infants developed definite atopic disease, and possible allergic diseases were noted in eight other infants. The IgE level at birth appeared to be more predictive for the development of allergy in infancy than the family history.
采用纸放射免疫吸附试验（PRIST）技术测定了136例新生儿及其母亲以及54例父亲的血清总IgE水平。用放射变应原吸附试验（RAST）检测针对屋尘（粉尘螨）、果园草、梯牧草和牛奶的IgE特异性抗体。133例新生儿的RAST检测为阴性，3例牛奶RAST检测为阳性。脐血IgE范围为0至5.5 IU/ml（平均0.32±0.54 IU/ml）；当母亲IgE超过100 IU/ml以及母亲在孕期接受过孕酮治疗时，IgE水平显著更高（p<0.05）。孕期使用沙丁胺醇或吸烟不影响新生儿IgE。对83例婴儿进行了为期9个月的临床随访研究。9例婴儿患了明确的特应性疾病，另外8例婴儿被记录有可能的过敏性疾病。出生时的IgE水平似乎比家族史更能预测婴儿期过敏的发生。
