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本文引用的文献

1
Lactylation of HADHA Promotes Sepsis-Induced Myocardial Depression.HADHA的乳酰化促进脓毒症诱导的心肌抑制。
Circ Res. 2025 Jun 27. doi: 10.1161/CIRCRESAHA.124.325708.
2
α-myosin heavy chain lactylation maintains sarcomeric structure and function and alleviates the development of heart failure.α-肌球蛋白重链乳酰化维持肌节结构和功能，并缓解心力衰竭的发展。
Cell Res. 2023 Sep;33(9):679-698. doi: 10.1038/s41422-023-00844-w. Epub 2023 Jul 13.
3
Lactate promotes endothelial-to-mesenchymal transition via Snail1 lactylation after myocardial infarction.乳酸通过心肌梗死后 Snail1 的乳酰化作用促进内皮细胞向间充质细胞转化。
Sci Adv. 2023 Feb 3;9(5):eadc9465. doi: 10.1126/sciadv.adc9465.
4
Mitochondrial pyruvate carrier 1 regulates fatty acid synthase lactylation and mediates treatment of nonalcoholic fatty liver disease.线粒体丙酮酸载体 1 调节脂肪酸合酶乳酰化并介导非酒精性脂肪性肝病的治疗。
Hepatology. 2023 Dec 1;78(6):1800-1815. doi: 10.1097/HEP.0000000000000279. Epub 2023 Jan 19.
5
Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.乳酰化组分析提示肝细胞癌中存在依赖乳酰化的代谢适应机制。
Nat Metab. 2023 Jan;5(1):61-79. doi: 10.1038/s42255-022-00710-w. Epub 2023 Jan 2.
6
Lactate promotes macrophage HMGB1 lactylation, acetylation, and exosomal release in polymicrobial sepsis.乳酸促进多微生物脓毒症中巨噬细胞 HMGB1 的乳酰化、乙酰化和胞外体释放。
Cell Death Differ. 2022 Jan;29(1):133-146. doi: 10.1038/s41418-021-00841-9. Epub 2021 Aug 6.
7
NAD Repletion Reverses Heart Failure With Preserved Ejection Fraction.NAD 补充剂可逆转射血分数保留型心力衰竭。
Circ Res. 2021 May 28;128(11):1629-1641. doi: 10.1161/CIRCRESAHA.120.317046. Epub 2021 Apr 22.
8
Metabolic regulation of gene expression by histone lactylation.组蛋白乳酰化对基因表达的代谢调控。
Nature. 2019 Oct;574(7779):575-580. doi: 10.1038/s41586-019-1678-1. Epub 2019 Oct 23.
9
Non-enzymatic N-acetylation of Lysine Residues by AcetylCoA Often Occurs via a Proximal S-acetylated Thiol Intermediate Sensitive to Glyoxalase II.乙酰辅酶A对赖氨酸残基的非酶促N-乙酰化作用通常通过对乙二醛酶II敏感的近端S-乙酰化硫醇中间体发生。
Cell Rep. 2017 Feb 28;18(9):2105-2112. doi: 10.1016/j.celrep.2017.02.018.
10
The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).《脓毒症及脓毒性休克第三次国际共识定义（脓毒症-3）》
JAMA. 2016 Feb 23;315(8):801-10. doi: 10.1001/jama.2016.0287.

Lactylation: A New Metabolic Signature of Sepsis-Related Cardiac Dysfunction.

作者信息

Arefeayne Nahum F, Kwong Jennifer Q

机构信息

Graduate Program in Biochemistry, Cell and Developmental Biology, Graduate Division of Biological and Biomedical Sciences, Emory University, Atlanta, GA (N.F.A.).

Division of Pediatric Cardiology, Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, GA (N.F.A., J.Q.K.).

出版信息

Circ Res. 2025 Aug;137(4):516-518. doi: 10.1161/CIRCRESAHA.125.326834. Epub 2025 Jul 31.

DOI:10.1161/CIRCRESAHA.125.326834
PMID:40743307
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12321204/
Abstract
摘要