Lalonde R, Botez M I
Behav Brain Res. 1985 Sep-Oct;17(2):83-6. doi: 10.1016/0166-4328(85)90020-8.
Nervous mutant mice have selective damage to deep cerebellar nuclei and Purkinje cells. Compared to normal littermate controls, nervous mutant mice did not show habituation of a hole poke response to a large hole. The nervous mutants showed both signs of increased contact with a novel stimulus (number of rearing responses) and decreased exploration (number of hole pokes in small holes). Results are discussed in terms of a similarity between the behavioral effects of cerebellar damage and hippocampal damage.
神经突变小鼠的小脑深部核团和浦肯野细胞有选择性损伤。与正常同窝对照小鼠相比，神经突变小鼠对大孔洞的戳洞反应未表现出习惯化。神经突变小鼠既表现出与新刺激接触增加的迹象（竖毛反应次数），又表现出探索减少（小孔洞的戳洞次数）。根据小脑损伤和海马体损伤行为效应之间的相似性对结果进行了讨论。
