Caston J, Chianale C, Delhaye-Bouchaud N, Mariani J
UPRES PSY.CO 1780, Laboratoire de Neurobiologie de l'Apprentissage, Université de Rouen, France.
Brain Res. 1998 Oct 19;808(2):232-7. doi: 10.1016/s0006-8993(98)00847-6.
Compared to +/+ mice, Lurcher (+/Lc) mutant mice whose cerebellar cortex is lacking almost all Purkinje cells and granule cells, exhibit a low level of exploration; this deficit is not due to a low level of activity but to both a decreased motivation to explore a novel environment and to spatial deficits. The characteristics of exploration in cerebellectomized +/+ and +/Lc mice suggest that the cerebellum is involved not only in cognitive but also in motivational processes.
与野生型（+/+）小鼠相比，Lurcher突变型（+/Lc）小鼠的小脑皮质几乎缺乏所有浦肯野细胞和颗粒细胞，其探索水平较低；这种缺陷并非由于活动水平低，而是由于探索新环境的动机降低和空间缺陷。小脑切除的野生型（+/+）和Lurcher突变型（+/Lc）小鼠的探索特征表明，小脑不仅参与认知过程，还参与动机过程。
