Lalonde R, Joyal C C, Guastavino J M, Botez M I
Hôtel-Dieu Hospital, Neurology Service, Montreal, Quebec, Canada.
Physiol Behav. 1993 Jul;54(1):41-4. doi: 10.1016/0031-9384(93)90041-d.
Lurcher mutant mice, a cerebellar mutant displaying ataxia and equilibrium deficits, had fewer hole pokes in a 16-hole matrix than normal mice. Lurcher mutants also took longer to reach a platform from a grid and to begin to climb a grid from the floor. However, the lurchers climbed as high as normal mice on the grid and their exploratory patterns of the holeboard were similar in many respects to normal mice, such as the ratio of center to peripheral hole exploration. In a wooden beam test, although lurchers did not differ from normal mice in terms of the amount of time spent on the beam or in the distance travelled, the mutants were found more often in unstable positions.
Lurcher突变小鼠是一种表现出共济失调和平衡缺陷的小脑突变体，与正常小鼠相比，它们在16孔矩阵中的戳孔次数更少。Lurcher突变体从网格到达平台以及从地面开始攀爬网格也需要更长的时间。然而，Lurcher小鼠在网格上攀爬的高度与正常小鼠一样高，并且它们在空板试验中的探索模式在许多方面与正常小鼠相似，例如中央孔与周边孔探索的比例。在木梁试验中，尽管Lurcher小鼠与正常小鼠在木梁上花费的时间或行进的距离方面没有差异，但发现突变体更常处于不稳定位置。
