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免疫功能正常的年轻女性中由黑曲霉引起的甲癣:一例罕见表现的病例报告

Onychomycosis Caused by Aspergillus niger in an Immunocompetent Young Female: A Case Report of a Rare Presentation.

作者信息

Aldairi Abdulrahman Saleh, Alsaedi Faris, Alotaibi Homaid

机构信息

Department of Dermatology, King Faisal Hospital, Ministry of Health, Makkah, SAU.

出版信息

Cureus. 2025 Jun 29;17(6):e87003. doi: 10.7759/cureus.87003. eCollection 2025 Jun.

DOI:10.7759/cureus.87003
PMID:40746799
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12310977/
Abstract

Onychomycosis is a fungal infection of the nail that may result from dermatophytes, non-dermatophyte molds, or yeasts. Among non-dermatophyte molds, Aspergillus niger is a recognized species with the potential to cause nail infections. While such infections were traditionally reported in immunocompromised individuals, they have also been increasingly observed in immunocompetent hosts. This condition carries clinical importance due to its potential for recurrence and resistance to treatment. Herein, we present a case of a 25-year-old immunocompetent female with a single fingernail onychomycosis caused by A. niger.

摘要

甲癣是一种由皮肤癣菌、非皮肤癣菌霉菌或酵母菌引起的指甲真菌感染。在非皮肤癣菌霉菌中,黑曲霉是一种公认的有可能引起指甲感染的菌种。虽然传统上此类感染多见于免疫功能低下的个体,但在免疫功能正常的宿主中也越来越多地观察到。由于其有复发和治疗耐药的可能性,这种疾病具有临床重要性。在此,我们报告一例由黑曲霉引起的、累及一名25岁免疫功能正常女性单指甲的甲癣病例。

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本文引用的文献

1
A Review of Onychomycosis Due to Aspergillus Species.曲霉属引起的甲真菌病综述。
Mycopathologia. 2018 Jun;183(3):485-493. doi: 10.1007/s11046-017-0222-9. Epub 2017 Nov 16.
2
A Case of Fingernail Onychomycosis due to Aspergillus flavus.一例由黄曲霉引起的指甲甲癣病例。
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3
Clinico-mycological study of dermatophyte toenail onychomycosis in new delhi, India.印度新德里皮肤癣菌性趾甲甲真菌病的临床真菌学研究
Indian J Dermatol. 2015 Mar-Apr;60(2):153-8. doi: 10.4103/0019-5154.152511.
4
Aspergillus species as emerging causative agents of onychomycosis.曲霉属作为甲癣的新兴致病原。
J Mycol Med. 2015 Jun;25(2):101-7. doi: 10.1016/j.mycmed.2014.12.001. Epub 2015 Feb 2.
5
British Association of Dermatologists' guidelines for the management of onychomycosis 2014.英国皮肤科医师协会2014年甲癣管理指南
Br J Dermatol. 2014 Nov;171(5):937-58. doi: 10.1111/bjd.13358.
6
A rare case of onychomycosis in all 10 fingers of an immunocompetent patient.一名免疫功能正常患者的10个手指均患甲癣的罕见病例。
Indian Dermatol Online J. 2013 Oct;4(4):302-4. doi: 10.4103/2229-5178.120649.
7
Fingernail Onychomycosis Due to Aspergillus niger.由黑曲霉引起的指甲甲癣
Ann Dermatol. 2012 Nov;24(4):459-63. doi: 10.5021/ad.2012.24.4.459. Epub 2012 Nov 8.
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Other fungi causing onychomycosis.其他引起甲真菌病的真菌。
Clin Dermatol. 2010 Mar 4;28(2):160-3. doi: 10.1016/j.clindermatol.2009.12.009.
9
Onychomycosis--epidemiology, diagnosis and management.甲癣——流行病学、诊断与治疗
Indian J Med Microbiol. 2008 Apr-Jun;26(2):108-16. doi: 10.4103/0255-0857.40522.
10
Clinical and histological aspects of toenail onychomycosis caused by Aspergillus spp.: 34 cases treated with weekly intermittent terbinafine.曲霉菌引起的趾甲甲癣的临床和组织学特征:34例患者接受每周间歇性特比萘芬治疗
Dermatology. 2004;209(2):104-10. doi: 10.1159/000079593.