Abrishamcar Sarina, Aqua Jasmine K, Dye Christian, Jones-Antwi Rebecca, Chen Yinxian, Gallo Linda C, Llabre Maria M, Perreira Krista M, Daviglus Martha L, Argos Maria, Thyagarajan Bharat, Hüls Anke, Baccarelli Andrea, Cai Jianwen, Isasi Carmen R, Kaplan Robert C, Conneely Karen N, Suglia Shakira F
Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA.
Epigenomics. 2025 Aug 1:1-13. doi: 10.1080/17501911.2025.2540260.
Hispanics/Latinos in the United States experience disproportionately high psychosocial factors compared to non-Hispanic/Latino Whites. Psychosocial factors may accelerate biological aging, measured by epigenetic age acceleration (EAA), a DNA methylation biomarker predictive of morbidity and mortality.
We investigated the cumulative impact of psychosocial factors on EAA over time in 922 adults from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Psychosocial exposure profiles were derived using self-organizing maps (SOM), an unsupervised clustering method. We calculated EAA from whole blood DNA methylation at two timepoints using GrimAge and DunedinPACE.
SOM identified four clusters: Cluster 1 ( = 196; 21.3%) had high levels of all psychosocial factors; Cluster 2 ( = 250; 27.1%) exhibited chronic, traumatic, and childhood stress; Cluster 3 ( = 250; 27.1%) showed mental health symptoms, low social support, and high perceived stress; and Cluster 4 ( = 238; 24.5%) had relatively low psychosocial stress. Adjusted weighted linear mixed models exhibited increased GrimAge in Cluster 1 (1.27 years, 95% CI: 0.57,1.97) and Cluster 2 (0.62 years, 95% CI: 0.01,1.23) compared to Cluster 4. DunedinPACE increased 3% (95% CI: 0.01,0.05) and 2% (95% CI: 0.001,0.04) in Clusters 1 and 3, respectively.
These findings highlight the cumulative impact of psychosocial factors on EAA and how stressors can get "under the skin" and contribute to health disparities.
与非西班牙裔/拉丁裔白人相比，美国的西班牙裔/拉丁裔经历的心理社会因素比例过高。心理社会因素可能会加速生物衰老，通过表观遗传年龄加速（EAA）来衡量，EAA是一种预测发病率和死亡率的DNA甲基化生物标志物。
我们在西班牙裔社区健康研究/拉丁裔研究（HCHS/SOL）的922名成年人中，调查了心理社会因素随时间对EAA的累积影响。心理社会暴露概况是使用自组织映射（SOM）得出的，这是一种无监督聚类方法。我们在两个时间点使用GrimAge和达尼丁PACE从全血DNA甲基化中计算EAA。
SOM识别出四个聚类：聚类1（n = 196；21.3%）所有心理社会因素水平都很高；聚类2（n = 250；27.1%）表现出慢性、创伤性和童年期压力；聚类3（n = 250；27.1%）表现出心理健康症状、低社会支持和高感知压力；聚类4（n = 238；24.5%）心理社会压力相对较低。与聚类4相比，调整后的加权线性混合模型显示聚类1（1.27年，95%置信区间：0.57，1.97）和聚类2（0.62年，95%置信区间：0.01，1.23）的GrimAge增加。聚类1和聚类3的达尼丁PACE分别增加3%（95%置信区间：0.01，0.05）和2%（95%置信区间：0.001，0.04）。
这些发现突出了心理社会因素对EAA的累积影响，以及压力源如何“深入肌肤”并导致健康差异。
