Novitskiĭ V V, Gol'dberg E D, Anyshakova N A
Antibiotiki. 1981 Dec;26(12):901-6.
The reserve potentialities of the hematopoietic tissue were studied on 216 albino noninbred rats with the use of various models of the hemopoiesis compensation and functional strain and morphofunctional methods 30 days after the treatment with carminomycin. It was shown that compensation potentialities of the bone marrow granulocytic fiber by the moment of the reduction of the quantitative and morphological composition of the white blood after the antibiotic treatment were characterized by complete depletion of the granulocytic capillary pool and decreased granulocyte reserve of the bone marrow. The treatment with the antibiotic resulted in a decreased erythropoietic reaction (as compared to the control) to the acute blood loss evident from suppressed activity of the bone marrow by the 24th--48th hour, decreased rates of the erythroid element proliferation, lower rates of the reticulocyte "washings" into the blood channel, decreased 24-hour production of the erythrocytes and a more pronounced decrease in the hemoglobin and erythrocyte levels in the early periods after the anemization. The blood loss had no significant effect on the proliferating activity of the granulocytic element of the bone marrow and induced no development of the posthemorrhagic leucocytosis. The reaction of the hemopoietic thrombocytic growing fiber to the anemic stress in the experimental animals was not adequate. It was characterized by the development of pronounced thrombocytopenia and impairment of normal thrombocyte formation in the bone marrow.
在用卡米诺霉素治疗30天后，利用各种造血补偿和功能应激模型以及形态功能方法，对216只白化非近交系大鼠的造血组织储备潜力进行了研究。结果表明，抗生素治疗后白细胞数量和形态组成减少时，骨髓粒细胞纤维的补偿潜力表现为粒细胞毛细血管池完全耗竭，骨髓粒细胞储备减少。抗生素治疗导致（与对照组相比）对急性失血的红细胞生成反应降低，这在第24至48小时骨髓活性受到抑制、红系元素增殖率降低、网织红细胞“洗出”到血循环的速率降低、红细胞24小时生成量减少以及贫血后早期血红蛋白和红细胞水平更明显下降中明显体现。失血对骨髓粒细胞成分的增殖活性没有显著影响，也未引发出血后白细胞增多。实验动物中造血血小板生长纤维对贫血应激的反应不充分。其特征是出现明显的血小板减少以及骨髓中正常血小板形成受损。
