空腹血糖升高所致气管、支气管和肺癌负担

Burden of Tracheal, Bronchus, and Lung Cancer Attributable to High Fasting Plasma Glucose.

作者信息

Zhou Jingyi, Xi Chenglong, Luan Zhiyu, Mao Lufeng, Ling Shiliang

机构信息

Department of Oncology, Ninghai Traditional Chinese Medicine Hospital, Ningbo, China.

Department of Oncology, Ningbo Municipal Hospital of Traditional Chinese Medicine, Affiliated Hospital of Zhejiang Chinese Medical University, Ningbo, China.

出版信息

Arch Iran Med. 2025 May 1;28(5):286-295. doi: 10.34172/aim.33332.

DOI:10.34172/aim.33332

PMID:40751522

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12305407/

Abstract

BACKGROUND

We aimed to evaluate the situation and change trends in the tracheal, bronchus, and lung (TBL) cancer burden attributable to high fasting plasma glucose (HFPG) stratified by gender, age, region, country, and sociodemographic index (SDI).

METHODS

We evaluated the age-standardized death rate (ASDR) and disability-adjusted life years (DALYs) rate of TBL cancer attributable to HFPG and their corresponding estimated annual percentage change (EAPC) trends in 204 countries and 21 regions.

RESULTS

Globally from 1990 to 2019, the ASDR (EAPC=0.98; 95% confidence interval [CI]: 0.82-1.15) and age-standardized DALY rate (EAPC=0.68; 95% CI: 0.55-0.82) of TBL cancer attributable to HFPG trended upward. Furthermore, the steepest increment in age-standardized death and DALY rates were noted in low-SDI regions (EAPC=1.32; EAPC=1.35) and the North Africa/Middle East region (EAPC=2.66, ESPC=2.56) among all five SDI regions and 21 global geographic regions, respectively. Among the 204 countries, the highest growth rate in the ASDR was found in Georgia (EAPC=4.33, 95% CI: 3.66-5.00), and the highest growth rate in the age-standardized DALY rate occurred in Egypt (EAPC=4.34, 95% CI: 4.22-4.47). The highest ASDR and age-standardized DALY rate occurred in people over the age of 65 years, and in the 21 geographic regions, SDIs were negatively correlated with ASDRs and EAPCs in DALYs.

CONCLUSION

The global burden of TBL cancer attributable to HFPG trended upward. The most significant increase in burden was observed in low-SDI regions and countries.

摘要

背景

我们旨在评估按性别、年龄、地区、国家和社会人口指数（SDI）分层的高空腹血糖（HFPG）所致气管、支气管和肺癌（TBL）癌症负担的情况及变化趋势。

方法

我们评估了204个国家和21个地区中HFPG所致TBL癌症的年龄标准化死亡率（ASDR）和伤残调整生命年（DALY）率及其相应的估计年变化百分比（EAPC）趋势。

结果

从1990年到2019年全球范围内，HFPG所致TBL癌症的ASDR（EAPC = 0.98；95%置信区间[CI]：0.82 - 1.15）和年龄标准化DALY率（EAPC = 0.68；95% CI：0.55 - 0.82）呈上升趋势。此外，在所有五个SDI地区和21个全球地理区域中，低SDI地区（EAPC = 1.32；EAPC = 1.35）和北非/中东地区（EAPC = 2.66，ESPC = 2.56）的年龄标准化死亡率和DALY率增幅最为显著。在204个国家中，ASDR增长率最高的是格鲁吉亚（EAPC = 4.33，95% CI：3.66 - 5.00），年龄标准化DALY率增长率最高的是埃及（EAPC = 4.34，95% CI：4.22 - 4.47）。最高的ASDR和年龄标准化DALY率出现在65岁以上人群中，并且在21个地理区域中，SDI与DALY的ASDR和EAPC呈负相关。