Carro-Ciampi G, Jurima M, Kadar D, Tang B K, Kalow W
Can J Physiol Pharmacol. 1985 Oct;63(10):1263-6. doi: 10.1139/y85-209.
N-Glucosidation is a novel pathway of barbiturate metabolism, so far known to occur only in man. A search for an animal model, conducted through in vitro screening, revealed that amobarbital-N-glucoside was formed in liver preparations from the cat. The presence of amobarbital-N-glucoside was demonstrated in cat urine, following i.p. administration of amobarbital.
N-葡萄糖苷化是巴比妥类药物代谢的一条新途径，迄今为止已知仅在人类中发生。通过体外筛选寻找动物模型，结果显示在猫的肝脏制剂中形成了异戊巴比妥-N-葡萄糖苷。腹腔注射异戊巴比妥后，在猫尿中证实了异戊巴比妥-N-葡萄糖苷的存在。
