Tang B K, Kalow W, Grey A A
Res Commun Chem Pathol Pharmacol. 1978 Jul;21(1):45-53.
N-Hydroxyamobarbital, the compound previously proposed as the second major metabolite of amobarbital was synthesized. The metabolite was shown not to be N-hydroxyamobarbital. NMR and MS analyses on the metabolite suggested it could be a derivative of N-beta-D-glucopyranoside. This proposed structure was confirmed by comparison with the spectral data of synthetic amobarbital-N-methyl-N-2,3,4,6-tetraacetyl-beta-D-glucopyranoside.
合成了曾被认为是异戊巴比妥第二主要代谢物的N-羟基异戊巴比妥。结果表明该代谢物并非N-羟基异戊巴比妥。对该代谢物的核磁共振和质谱分析表明它可能是N-β-D-吡喃葡萄糖苷的衍生物。通过与合成的异戊巴比妥-N-甲基-N-2,3,4,6-四乙酰基-β-D-吡喃葡萄糖苷的光谱数据进行比较，证实了所提出的结构。
