Tang B K, Grey A A, Reilly P A, Kalow W
Can J Physiol Pharmacol. 1980 Oct;58(10):1167-9. doi: 10.1139/y80-176.
Amobarbital is almost completely metabolized in animals and man. The major metabolite is 3'-hydroxyamobarbital. The second major metabolite in dog, mice, hamsters, guinea pigs, and rats could be identified as 3',4'-dihydroxyamobarbital. A striking contrast between man and animals is the virtual absence of the diol in man and absence of amobarbital-N-glucoside in animals.
异戊巴比妥在动物和人体内几乎完全代谢。主要代谢产物是3'-羟基异戊巴比妥。在狗、小鼠、仓鼠、豚鼠和大鼠体内，第二主要代谢产物可鉴定为3',4'-二羟基异戊巴比妥。人与动物之间的一个显著差异是，人体内几乎不存在二醇，而动物体内不存在异戊巴比妥-N-葡萄糖苷。
