Hou Zhenxing, Wang Haoran, He Bing, Wang Qichao, Gao Yanzheng
Department of Spinal Cord Surgery, People's Hospital of Henan University, Zhengzhou, 450003, China.
Cardiovascular Institute of Luohe, Luohe Central Hospital, Luohe Medical College, Luohe, 462003, China.
Sci Rep. 2025 Aug 3;15(1):28302. doi: 10.1038/s41598-025-12925-4.
To investigate the relationship between glycemic indicators (HbA1c and FPG) and bone mineral density (BMD) as well as osteoporosis in adults. A total of 1445 participants from the "The longitudinal investigation of osteoarthritis and cardiovascular health status" cohort were recruited and classified into normal BMD, osteopenia, and osteoporosis groups based on BMD. Data on sociodemographic factors, anthropometric measurements, medical history, and FPG samples were collected. BMD was measured by tibial ultrasound. Logistic regression analysis was performed to calculate the Odds Ratio (OR) and 95% confidence interval (CI), with adjustments for confounding factors. Participants in the osteopenia and osteoporosis groups were older, had higher triglycerides and body mass index, and fewer smokers and alcohol consumers compared to the normal BMD group. HbA1c levels were significantly lower in the osteopenia and osteoporosis groups than in the normal BMD group, while FPG showed no significant differences. Logistic regression indicated a significant negative correlation between HbA1c and the risk of osteoporosis (OR (95% CI) 0.914 (0.838, 0.997)) and osteopenia (OR (95% CI) 0.904 (0.826, 0.989)). After adjusting for confounding factors, a significant positive correlation exists between HbA1c and BMD, and higher HbA1c levels are associated with a relatively lower risk of osteoporosis. These findings highlight the importance of considering long-term blood glucose control in clinical practice for bone health management.
研究成人血糖指标（糖化血红蛋白和空腹血糖）与骨密度以及骨质疏松症之间的关系。从“骨关节炎与心血管健康状况纵向调查”队列中招募了1445名参与者，并根据骨密度将其分为骨密度正常、骨量减少和骨质疏松组。收集了社会人口统计学因素、人体测量学、病史和空腹血糖样本的数据。通过胫骨超声测量骨密度。进行逻辑回归分析以计算优势比（OR）和95%置信区间（CI），并对混杂因素进行调整。与骨密度正常组相比，骨量减少和骨质疏松组的参与者年龄更大，甘油三酯和体重指数更高，吸烟者和饮酒者更少。骨量减少和骨质疏松组的糖化血红蛋白水平显著低于骨密度正常组，而空腹血糖无显著差异。逻辑回归表明糖化血红蛋白与骨质疏松症风险（OR（95%CI）0.914（0.838，0.997））和骨量减少风险（OR（95%CI）0.904（0.826，0.989））之间存在显著负相关。在调整混杂因素后，糖化血红蛋白与骨密度之间存在显著正相关，较高的糖化血红蛋白水平与相对较低的骨质疏松症风险相关。这些发现凸显了在临床实践中考虑长期血糖控制对骨骼健康管理的重要性。
