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将人工智能纳入骨折风险评估:利用临床影像预测不可预测之事。

Incorporating Artificial Intelligence into Fracture Risk Assessment: Using Clinical Imaging to Predict the Unpredictable.

作者信息

Kong Sung Hye

机构信息

Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.

出版信息

Endocrinol Metab (Seoul). 2025 Aug;40(4):499-507. doi: 10.3803/EnM.2025.2518. Epub 2025 Aug 4.

Abstract

Artificial intelligence (AI) is increasingly being explored as a complementary tool to traditional fracture risk assessment methods. Conventional approaches, such as bone mineral density measurement and established clinical risk calculators, provide populationlevel stratification but often fail to capture the structural nuances of bone fragility. Recent advances in AI-particularly deep learning techniques applied to imaging-enable opportunistic screening and individualized risk estimation using routinely acquired radiographs and computed tomography (CT) data. These models demonstrate improved discrimination for osteoporotic fracture detection and risk prediction, supporting applications such as time-to-event modeling and short-term prognosis. CT- and radiograph-based models have shown superiority over conventional metrics in diverse cohorts, while innovations like multitask learning and survival plots contribute to enhanced interpretability and patient-centered communication. Nevertheless, challenges related to model generalizability, data bias, and automation bias persist. Successful clinical integration will require rigorous external validation, transparent reporting, and seamless embedding into electronic medical systems. This review summarizes recent advances in AI-driven fracture assessment, critically evaluates their clinical promise, and outlines a roadmap for translation into real-world practice.

摘要

人工智能(AI)正越来越多地被作为传统骨折风险评估方法的辅助工具进行探索。传统方法,如骨密度测量和既定的临床风险计算器,可提供人群水平的分层,但往往无法捕捉骨脆性的结构细微差别。人工智能的最新进展,特别是应用于成像的深度学习技术,能够利用常规获取的X光片和计算机断层扫描(CT)数据进行机会性筛查和个性化风险估计。这些模型在骨质疏松性骨折检测和风险预测方面表现出更好的辨别能力,支持诸如事件发生时间建模和短期预后等应用。基于CT和X光片的模型在不同队列中已显示出优于传统指标的优势,而多任务学习和生存曲线等创新有助于提高可解释性和以患者为中心的沟通。然而,与模型通用性、数据偏差和自动化偏差相关的挑战依然存在。成功的临床整合将需要严格的外部验证、透明的报告以及无缝嵌入电子医疗系统。本综述总结了人工智能驱动的骨折评估的最新进展,批判性地评估了它们的临床前景,并概述了转化为实际临床应用的路线图。

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