Miqdad Mohammed A, Al-Saedi Zainulabdeen S, Alatta Lina, Hulwi Hasan, Kuo Sheng
Research, Michigan State University, East Lansing, USA.
Nephrology, NewYork-Presbyterian, New York, USA.
Cureus. 2025 Jul 4;17(7):e87285. doi: 10.7759/cureus.87285. eCollection 2025 Jul.
Lupus nephritis (LN) is a common complication of systemic lupus erythematosus (SLE) and often presents as an immune complex-mediated glomerular disease. While pauci-immune crescentic glomerulonephritis (PICG) is commonly associated with antineutrophil cytoplasmic antibodies (ANCAs), its occurrence in the context of LN is rare. We report a case of an SLE patient who developed acute kidney injury due to ANCA-negative PICG. The kidney injury was severe enough to necessitate renal replacement therapy; however, the patient responded well to treatment. We also review the literature and previously reported cases of PICG in patients with SLE.
狼疮性肾炎（LN）是系统性红斑狼疮（SLE）的常见并发症，常表现为免疫复合物介导的肾小球疾病。虽然寡免疫性新月体性肾小球肾炎（PICG）通常与抗中性粒细胞胞浆抗体（ANCA）相关，但其在LN背景下的发生却很罕见。我们报告一例SLE患者，该患者因ANCA阴性的PICG而发生急性肾损伤。肾损伤严重到需要进行肾脏替代治疗；然而，患者对治疗反应良好。我们还回顾了文献以及先前报道的SLE患者中PICG的病例。
