Xiao Hu, Lu Da Qian, Cheung Jimmy Ka-Wai, Sze Ying Hon, Bian Jing Fang, Do Chi-Wai, Zhou Lei, Xing Xiao Li, Lam Thomas Chuen
The Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen, Guangdong, PR China.
Centre for Myopia Research, School of Optometry, The Hong Kong Polytechnic University, Hong Kong.
Data Brief. 2025 Jul 11;61:111881. doi: 10.1016/j.dib.2025.111881. eCollection 2025 Aug.
Primary open-angle glaucoma (POAG) is the foremost cause of irreversible visual impairment, attributed to a complex array of ocular diseases. The lack of reliable prognostic indicators necessitates the development of biomarkers that can be used to detect and monitor glaucoma early in its course. In this study, human aqueous humor databases dedicated to advanced and not advanced POAG from Chinese were compiled to facilitate research on POAG, using advanced label-free quantitative proteomics technology by a TimsTOF Pro mass spectrometer. Proteins and peptides were identified and quantified by DIA-NN bioinformatics. All mass spectrometry data were deposited in the ProteomeXchange Consortium via the PRIDE partner (https://www.ebi.ac.uk/pride) with the dataset identifier PRIDE: PXD060484.
原发性开角型青光眼（POAG）是不可逆视力损害的首要原因，这归因于一系列复杂的眼部疾病。由于缺乏可靠的预后指标，因此有必要开发可用于在青光眼病程早期进行检测和监测的生物标志物。在本研究中，利用TimsTOF Pro质谱仪的先进无标记定量蛋白质组学技术，编制了来自中国的、针对晚期和非晚期POAG的人房水数据库，以促进对POAG的研究。通过DIA-NN生物信息学对蛋白质和肽进行鉴定和定量。所有质谱数据均通过PRIDE合作伙伴（https://www.ebi.ac.uk/pride）存入蛋白质组交换联盟，数据集标识符为PRIDE:PXD060484。
