Tang Shuang, Wang Yaoxin, Ma Ping, Fan Zhipeng
Beijing Institute of Dental Research, Beijing Stomatological Hospital, School of Stomatology, Capital Medical University Beijing China.
Laboratory of Molecular Signaling and Stem Cells Therapy, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Beijing Stomatological Hospital, School of Stomatology, Capital Medical University Beijing China
RSC Adv. 2025 Aug 1;15(34):27452-27466. doi: 10.1039/d5ra03550c.
Zirconia implants are increasingly prevalent in dental applications due to their superior aesthetic outcomes, excellent mechanical properties, and remarkable biocompatibility. However, zirconia implants face challenges such as insufficient bioactivity and limited osseointegration capability, which compromise their long-term stability. In this study, porous titania (TiO) coatings were developed on zirconia surfaces to enhance their osteogenic activity. Zirconia substrates were immersed in a mixed solution of zirconium oxychloride (ZrOCl) and TiO in a water bath. By regulating the concentration of the treatment solution according to the hydrolysis characteristics of ZrOCl, TiO coatings with different porous morphologies were formed during the dense sintering process of zirconia ceramics. The surface characteristics, mechanical strength and bonding strength of coatings of different zirconia samples were tested. The MC3T3-E1 cells were seeded on zirconia discs to evaluate the bioactivity of porous TiO coatings. To assess the response of porous TiO-coated zirconia, the samples were implanted into rat femurs, followed by systematic analysis. Firmly bonded porous TiO coatings were generated on the zirconia surface, significantly enhancing surface roughness and hydrophilicity without adversely affecting the mechanical strength of zirconia. Through cell experiments, porous TiO-modified zirconia could promote cell proliferation, spreading and osteogenic differentiation. Furthermore, assessments confirmed that porous TiO-coated zirconia exhibited superior osseointegration effect. The preparation of porous TiO-coated zirconia is an effective method to improve the osteogenic performance of zirconia implants, which is of significant importance for promoting the widespread application of zirconia implants.
由于氧化锆植入物具有出色的美学效果、优异的机械性能和卓越的生物相容性，它们在牙科应用中越来越普遍。然而，氧化锆植入物面临着诸如生物活性不足和骨整合能力有限等挑战，这会影响它们的长期稳定性。在本研究中，在氧化锆表面制备了多孔二氧化钛（TiO）涂层以增强其成骨活性。将氧化锆基底浸入含有氧氯化锆（ZrOCl）和TiO的混合溶液中并置于水浴中。根据ZrOCl的水解特性调节处理溶液的浓度，在氧化锆陶瓷的致密烧结过程中形成具有不同多孔形态的TiO涂层。测试了不同氧化锆样品涂层的表面特性、机械强度和结合强度。将MC3T3-E1细胞接种在氧化锆圆盘上以评估多孔TiO涂层的生物活性。为了评估多孔TiO涂层氧化锆的反应，将样品植入大鼠股骨中，然后进行系统分析。在氧化锆表面生成了牢固结合且多孔的TiO涂层，显著提高了表面粗糙度和亲水性，同时不会对氧化锆的机械强度产生不利影响。通过细胞实验，多孔TiO改性的氧化锆可促进细胞增殖、铺展和成骨分化。此外，评估证实多孔TiO涂层的氧化锆表现出优异的骨整合效果。制备多孔TiO涂层氧化锆是提高氧化锆植入物成骨性能的有效方法，这对于促进氧化锆植入物的广泛应用具有重要意义。
