Edouard L, Doucet F, Buxtorf J C, Beaumont J L
Clin Physiol Biochem. 1985;3(6):323-9.
A new technique is described for the determination of cholesterol in skin biopsies which is sensitive, practical and reproducible. The determination of cutaneous cholesterol is of clinical interest, because of its correlation with the degree of atherosclerosis. There was no correlation found between the blood total cholesterol and total triglycerides, and cholesterol and triglycerides determined in the skin biopsies. Determinations were carried out on several normal subjects, 7 long-distance runners, 34 hyperlipidemic patients. There was a significant increase with age of total skin cholesterol in the normal subjects, the values obtained with the long-distance runners had a tendency to be somewhat lower. All the patients investigated had higher cholesterol values than the normal controls or the sportsmen. This technique can be used therefore as a diagnostic tool to detect pathologies of skin lipids, or of tissue lipid metabolism, as for example in normolipidemic patients presenting corneal arcus or xanthelasmas.
本文描述了一种用于测定皮肤活检组织中胆固醇的新技术，该技术灵敏、实用且可重复。皮肤胆固醇的测定具有临床意义，因为它与动脉粥样硬化程度相关。在血液总胆固醇和总甘油三酯与皮肤活检组织中测定的胆固醇和甘油三酯之间未发现相关性。对多名正常受试者、7名长跑运动员、34名高脂血症患者进行了测定。正常受试者皮肤总胆固醇随年龄显著增加，长跑运动员的测定值有略低的趋势。所有受调查患者的胆固醇值均高于正常对照组或运动员。因此，该技术可作为一种诊断工具，用于检测皮肤脂质或组织脂质代谢的病变，例如在出现角膜弓或睑黄瘤的血脂正常患者中。
