利用电影磁共振成像评估健康受试者和功能性消化不良患者的胃蠕动
Evaluation of Gastric Peristalsis Using Cine MRI in Healthy Subjects and Patients With Functional Dyspepsia.
作者信息
Oki Shotaro, Takeda Tsutomu, Hojo Mariko, Nakamura Shunsuke, Kanazawa Takuya, Yamamoto Momoko, Iwano Tomoyo, Utsunomiya Hisanori, Uchida Ryota, Abe Daiki, Suzuki Nobuyuki, Ikeda Atsushi, Akazawa Yoichi, Ueda Kumiko, Ueyama Hiroya, Shibuya Tomoyoshi, Nojiri Shuko, Asaoka Daisuke, Todisco Andrea, Sato Shuji, Kuwatsuru Ryohei, Nagahara Akihito
机构信息
Department of Gastroenterology, Juntendo University Faculty of Medicine, Tokyo, Japan.
Department of Pathophysiological Research and Therapeutics for Gastrointestinal Diseases, Juntendo University Tokyo, Japan.
出版信息
Clin Transl Gastroenterol. 2025 Sep 1;16(9):e00900. doi: 10.14309/ctg.0000000000000900.
INTRODUCTION
Functional dyspepsia (FD) is subdivided into postprandial distress syndrome (PDS) and epigastric pain syndrome (EPS), each with a different pathophysiological mechanisms driving the symptoms of these syndromes. Cine MRI aids observation in any continuous cross-section and measures gastrointestinal peristalsis without radiation exposure. In this study, we aimed to evaluate gastric peristalsis in FD using cine MRI.
METHODS
This study was a prospective interventional study. Patients diagnosed with FD according to ROME IV diagnostic criteria were included. Cine MRI was performed before and after the test meal. Gastric maximum short axis diameter, amplitude, contraction frequency, peristaltic wave height, peristaltic wave velocity, and gastric motility index were evaluated and compared between healthy control (HC) and patients with FD (PDS/EPS).
RESULTS
This study consisted of 18 HC and 31 patients with FD (including 22 with PDS and 9 with EPS). Preprandial comparison of the HC, PDS, and EPS groups showed no significant difference. Postprandial comparison of the 3 groups showed significant differences in maximum short axis diameter of fornix (HC: 51.5 ± 9.1/PDS: 47.1 ± 10.3/EPS: 59.0 ± 13.6 mm, P = 0.045), amplitude of fornix (HC: 7.3 ± 5.1/PDS: 12.1 ± 4.3/EPS: 11.3 ± 8.7 mm, P = 0.009), contraction frequency (HC: 2.9 ± 0.3/PDS: 2.7 ± 0.5/EPS: 2.6 ± 0.2 times/min, P = 0.007), peristaltic wave height (HC: 14.9 ± 4.0/PDS: 9.2 ± 2.5/EPS: 9.5 ± 3.2 mm, P < 0.001), and gastric motility index (HC: 24.5 ± 7.1/PDS: 16.8 ± 6.1/EPS: 15.9 ± 6.3 mm 2 /s, P = 0.002).
DISCUSSION
Cine MRI can be used to visually evaluate gastric peristalsis dysfunction and impaired gastric accommodation in FD.
引言
功能性消化不良（FD）可细分为餐后不适综合征（PDS）和上腹痛综合征（EPS），每种综合征的症状由不同的病理生理机制驱动。电影磁共振成像（Cine MRI）有助于在任何连续横截面上进行观察，并可测量胃肠蠕动，且无辐射暴露。在本研究中，我们旨在使用电影磁共振成像评估FD患者的胃蠕动。
方法
本研究为前瞻性干预研究。纳入根据罗马IV诊断标准诊断为FD的患者。在试餐前后进行电影磁共振成像检查。评估并比较健康对照（HC）组和FD患者（PDS/EPS）组的胃最大短轴直径、幅度、收缩频率、蠕动波高度、蠕动波速度和胃动力指数。
结果
本研究包括18名HC患者和31名FD患者（包括22名PDS患者和9名EPS患者）。HC组、PDS组和EPS组餐前比较无显著差异。三组餐后比较显示，穹窿最大短轴直径（HC：51.5±9.1/PDS：47.1±10.3/EPS：59.0±13.6mm，P = 0.045）、穹窿幅度（HC：7.3±5.1/PDS：12.1±4.3/EPS：11.3±8.7mm，P = 0.009）、收缩频率（HC：2.9±0.3/PDS：2.7±0.5/EPS：2.6±0.2次/分钟，P = 0.007）、蠕动波高度（HC：14.9±4.0/PDS：9.2±2.5/EPS：9.5±3.2mm，P < 0.001）和胃动力指数（HC：24.5±7.1/PDS：16.8±6.1/EPS：15.9±6.3mm²/s，P = 0.002）存在显著差异。
讨论
电影磁共振成像可用于直观评估FD患者的胃蠕动功能障碍和胃容纳功能受损情况。
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