Madlala Hlengiwe P, Chen Junyu, Jao Jennifer, Myer Landon, Mendham Amy E, Pheiffer Carmen, Bell Liam, Dugas Lara R, Goedecke Julia H, Sun Yan V, Bengtson Angela M
Division of Epidemiology and Biostatistics, School of Public Health, University of Cape Town, Falmouth Building, Anzio Road, Observatory, Cape Town, 7925, South Africa.
Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
AIDS Res Ther. 2025 Aug 4;22(1):76. doi: 10.1186/s12981-025-00782-0.
Postpartum adiposity is associated with long-term risk of cardiovascular disease (CVD), which may be influenced by HIV infection. We investigated cross-sectional correlations between postpartum adiposity measures, and circulating proteins linked to CVD in women living with and without HIV. Irrespective of HIV status, adiposity was positively correlated with fatty acid binding protein 4, leptin and galectin 9; and negatively correlated with insulin-like growth factor binding protein 2 and V-set immunoglobulin domain containing 2. The link between adiposity and CVD-linked circulating proteins underscores the role of protein markers in understanding the cardiometabolic health of postpartum women living with and without HIV. Clinical trial number: Not applicable.
产后肥胖与心血管疾病（CVD）的长期风险相关，这可能受到HIV感染的影响。我们调查了产后肥胖指标与感染和未感染HIV的女性中与CVD相关的循环蛋白之间的横断面相关性。无论HIV感染状态如何，肥胖与脂肪酸结合蛋白4、瘦素和半乳糖凝集素9呈正相关；与胰岛素样生长因子结合蛋白2和含V-set免疫球蛋白结构域的蛋白2呈负相关。肥胖与CVD相关循环蛋白之间的联系强调了蛋白质标志物在理解感染和未感染HIV的产后女性心脏代谢健康方面的作用。临床试验编号：不适用。
