Ahmad Muhammad, Ali Aizaz, Mari Tahreem, Hasan Fariha, Ali Saeed, Sharbatji Mohamad, Khan Malik Waleed Zeb, Ikram Jibran
Department of Medicine, Khyber Medical College, Peshawar, Pakistan.
Department of Medicine, Dow University of Health Sciences, Karachi, Pakistan.
J Gastrointest Cancer. 2025 Aug 5;56(1):168. doi: 10.1007/s12029-025-01295-9.
Gastric malignancies remain a significant public health concern and a major contributor to cancer-related mortality worldwide. This study aimed to analyze trends and disparities in gastric malignancy mortality across socio-demographic and regional factors in the United States (US) from 1999 to 2020.
A retrospective analysis was conducted using CDC WONDER data from 1999 to 2020 for adults aged ≥ 25 years. Data on demographics (age, sex, race/ethnicity), urban-rural classification, and regional trends were extracted. Age-adjusted mortality rates (AAMR) were calculated using the 2000 U.S. population as a reference, with trends analyzed using Joinpoint regression to determine annual percentage changes (APC) with statistical significance (P < 0.05).
Between 1999 and 2020, 276,023 deaths due to gastric malignancies were recorded, with 59.3% occurring among males. The AAMR declined from 7.94 in 1999 to 4.66 in 2020, with an overall AAMR of 5.82. The 65 + age group had the highest AAMR (20.83), while the 25-44 age group had the lowest (0.74). Males consistently reported higher AAMRs (7.60) than females (4.85). NH Black individuals had the highest overall AAMR (10.82), while NH White individuals had the lowest (4.62). Urban areas had higher AAMRs (5.95) than rural areas (5.07).
Mortality from gastric malignancies has declined in the U.S. from 1999 to 2020; however, higher mortality rates in NH Black individuals, males, and urban dwellers highlight the need for targeted interventions and equitable access to prevention and treatment resources. Future research should focus on identifying actionable solutions to mitigate these gaps.
胃癌仍是一个重大的公共卫生问题，也是全球癌症相关死亡的主要原因之一。本研究旨在分析1999年至2020年美国社会人口和区域因素导致的胃癌死亡率的趋势和差异。
使用美国疾病控制与预防中心（CDC）1999年至2020年针对年龄≥25岁成年人的WONDER数据进行回顾性分析。提取了人口统计学数据（年龄、性别、种族/民族）、城乡分类和区域趋势数据。以2000年美国人口为参考计算年龄调整死亡率（AAMR），使用Joinpoint回归分析趋势以确定具有统计学意义（P<0.05）的年度百分比变化（APC）。
1999年至2020年期间，记录了276,023例胃癌死亡病例，其中59.3%发生在男性中。AAMR从1999年的7.94降至2020年的4.66，总体AAMR为5.82。65岁及以上年龄组的AAMR最高（为20.83），而25 - 44岁年龄组的AAMR最低（为0.74）。男性的AAMR始终高于女性（分别为7.60和4.85）。非西班牙裔黑人个体的总体AAMR最高（为10.82），而非西班牙裔白人个体的AAMR最低（为4.62）。城市地区的AAMR（为5.95）高于农村地区（为5.07）。
1999年至2020年期间，美国胃癌死亡率有所下降；然而，非西班牙裔黑人个体、男性和城市居民的较高死亡率凸显了有针对性干预措施以及公平获得预防和治疗资源的必要性。未来的研究应侧重于确定可采取行动的解决方案以缩小这些差距。
