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Comparison of the pharmacokinetic profile of metaclazepam in old and young volunteers.

作者信息

Molz K H, Gielsdorf W, Rasper J, Jaeger H, Hausleiter H J, Achtert G, Philipp P

出版信息

Eur J Clin Pharmacol. 1985;29(2):247-9. doi: 10.1007/BF00547431.

DOI:10.1007/BF00547431
PMID:4076323
Abstract

A single-centre, open, Phase I-study comparison of the pharmacokinetics of a single dose of metaclazepam 10 mg, a new 1,4-benzodiazepine has been done in 10 older and 20 younger volunteers. No important age-related effect was found on the kinetics of metaclazepam or its N-desmethyl derivative, the principal metabolite in man.

摘要

相似文献

1
Comparison of the pharmacokinetic profile of metaclazepam in old and young volunteers.
Eur J Clin Pharmacol. 1985;29(2):247-9. doi: 10.1007/BF00547431.
2
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引用本文的文献

1
Pharmacokinetic profile of metaclazepam (Talis), a new 1.4-benzodiazepine. Influence of different dosage regimens on the pharmacokinetic profile of metaclazepam and its main metabolite under steady-state conditions.新型1,4-苯二氮䓬类药物美他氯氮䓬（Talis）的药代动力学特征。不同给药方案对稳态条件下美他氯氮䓬及其主要代谢产物药代动力学特征的影响。
Eur J Drug Metab Pharmacokinet. 1986 Jul-Sep;11(3):205-10. doi: 10.1007/BF03189848.
2
Hepatic drug metabolism and aging.肝脏药物代谢与衰老
Clin Pharmacokinet. 1990 Nov;19(5):359-89. doi: 10.2165/00003088-199019050-00002.
3
Clinical pharmacokinetics of anxiolytics and hypnotics in the elderly. Therapeutic considerations (Part II).

本文引用的文献

1
Oxazepam kinetics: effects of age and sex.奥沙西泮动力学：年龄和性别的影响。
J Pharmacol Exp Ther. 1980 Oct;215(1):86-91.
2
[Drug dosage in the aged].[老年人的药物剂量]
Med Welt. 1981 Feb 13;32(7):225-8.
3
Drug therapy: drug disposition in old age.药物治疗：老年人的药物处置
老年人中抗焦虑药和催眠药的临床药代动力学。治疗考量（第二部分）
Clin Pharmacokinet. 1991 Oct;21(4):262-73. doi: 10.2165/00003088-199121040-00003.
N Engl J Med. 1982 May 6;306(18):1081-8. doi: 10.1056/NEJM198205063061804.
4
Clinical pharmacology: drugs and the elderly.临床药理学：药物与老年人
Br Med J (Clin Res Ed). 1981 Jan 10;282(6258):125-7. doi: 10.1136/bmj.282.6258.125.
5
[Drugs and the aged].[药物与老年人]
Med Monatsschr Pharm. 1983 Sep;6(9):269-74.
6
Treating anxiety in elderly patients.治疗老年患者的焦虑症。
Geriatrics. 1983 Oct;38(10):115-9.
7
Drug treatment of anxiety and agitation in the aged.
Psychopharmacol Bull. 1983 Spring;19(2):238-46.
8
Pharmacokinetic comparisons.药代动力学比较
Psychosomatics. 1980 Oct;21(Suppl):9-14. doi: 10.1016/s0033-3182(80)73598-3.
9
The effects of age and liver disease on the disposition and elimination of diazepam in adult man.年龄和肝脏疾病对成年男性体内地西泮处置与消除的影响。
J Clin Invest. 1975 Feb;55(2):347-59. doi: 10.1172/JCI107938.
10
Human pharmacokinetics of nitrazepam: effect of age and diseases.
Eur J Clin Pharmacol. 1979 Apr 17;15(3):163-70. doi: 10.1007/BF00563100.