Cergole-Novella Maria Cecilia, Bispo Thayná Rosa, Matsuda Elaine Monteiro, Colpas Daniela Rodrigues, Campos Ivana Barros de
Instituto Adolfo Lutz, Centro de Laboratório Regional Santo André, Santo André, SP, Brazil.
Prefeitura Municipal de Santo André, Secretaria de Saúde de Santo André, Santo André, SP, Brazil.
Braz J Infect Dis. 2025 Aug 4;29(5):104571. doi: 10.1016/j.bjid.2025.104571.
SARS-CoV-2 predominantly affects the respiratory system; however, during the first pandemic wave, there was a concern about its neuroinvasive potential due to its ability to replicate in neural cells and the neurological signs widely reported as impaired taste or smell. This study aimed to evaluate the presence of SARS-CoV-2 in cerebrospinal fluid (CSF) from suspected cases of meningitis. During the first year of the pandemic, from January 2020 to February 2021, CSF samples were first submitted to multiplex qPCR to detect the three main bacteria causing meningitis (Neisseria meningitidis, Streptococcus pneumoniae, and Haemophilus influenzae), as the routine of the laboratory, but also, they were submitted to RT-qPCR to SARS-CoV-2 detection. Some samples (20 %) were positive for one bacterium; however, none were positive for the virus, suggesting that the incidence of SARS-CoV-2 in meninges is extremely low. This study with other data in the literature contributes to the epidemiologic surveillance of SARS-CoV-2.
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）主要影响呼吸系统；然而，在疫情的第一波期间，由于其在神经细胞中复制的能力以及广泛报道的味觉或嗅觉受损等神经学症状，人们对其神经侵袭潜力感到担忧。本研究旨在评估疑似脑膜炎病例脑脊液（CSF）中SARS-CoV-2的存在情况。在疫情的第一年，即2020年1月至2021年2月，脑脊液样本首先按照实验室常规进行多重定量聚合酶链反应（qPCR），以检测引起脑膜炎的三种主要细菌（脑膜炎奈瑟菌、肺炎链球菌和流感嗜血杆菌），同时也进行逆转录定量聚合酶链反应（RT-qPCR）以检测SARS-CoV-2。一些样本（20%）对一种细菌呈阳性；然而，没有一个样本对病毒呈阳性，这表明SARS-CoV-2在脑膜中的发生率极低。这项研究与文献中的其他数据有助于SARS-CoV-2的流行病学监测。
