Yin Zhicheng, Tian Yingying, Huang Shuteng, Wang Hong, Zhao Lili, Zhang Ruyue, Cai Desheng, Wang Shuping, Zhong Shaojing, Zhang Jiayu
School of Traditional Chinese Medicine Binzhou Medical University Yantai China.
College of Pharmaceutical Science Shandong University of Traditional Chinese Medicine Jinan China.
Food Sci Nutr. 2025 Aug 5;13(8):e70578. doi: 10.1002/fsn3.70578. eCollection 2025 Aug.
Food-borne marine active peptides have been increasingly used as functional products for postoperative rehabilitation. However, there are still many problems, such as low protein yield and absorption rate. Therefore, the assisted enzymatic hydrolysis process and activity of marine immunoreactive peptides have been the focus of widespread attention. In particular, they are used as natural immunomodulators to improve intestinal microbiota and immune damage. Most peptides are barely digested by the gastrointestinal tract, especially in the immune microenvironment-damaged intestine. How to make the damaged intestine fully absorb active substances has become an urgent problem to be solved in food distribution. Therefore, the optimization process method is summarized to improve the quality and efficiency, and according to the immune activity mechanism combined with peptide self-assembly food application, which provides an alternative for the design of functional products. Sustained release of peptide-derived hydrogels increases their retention time in the body and promotes complete absorption in the gastrointestinal tract. By targeting release and enhancing biologically active functions, peptides avoid enzymatic hydrolysis in the gastrointestinal tract, thereby improving the stability of food-derived immunoactive peptide delivery. Moreover, with the increasing correlation between food-borne products and intestinal flora, the active sites of food-borne immunoactive peptides and metal ion chelating peptides are more conducive to the micro-regulation of intestinal flora. This review provides an opportunity for food and drug applications and development related to immunotherapy.
食源海洋活性肽已越来越多地被用作术后康复的功能性产品。然而，仍然存在许多问题，如蛋白质产量低和吸收率低等。因此，海洋免疫反应性肽的辅助酶解过程和活性一直是广泛关注的焦点。特别是，它们被用作天然免疫调节剂来改善肠道微生物群和免疫损伤。大多数肽在胃肠道中几乎不被消化，尤其是在免疫微环境受损的肠道中。如何使受损肠道充分吸收活性物质已成为食品配送中亟待解决的问题。因此，总结优化工艺方法以提高质量和效率，并根据免疫活性机制结合肽自组装食品应用，为功能性产品的设计提供了一种选择。肽衍生水凝胶的缓释增加了它们在体内的保留时间，并促进在胃肠道中的完全吸收。通过靶向释放和增强生物活性功能，肽避免了在胃肠道中的酶解，从而提高了食源免疫活性肽递送的稳定性。此外，随着食源产品与肠道菌群之间的相关性增加，食源免疫活性肽和金属离子螯合肽的活性位点更有利于肠道菌群的微调节。本综述为免疫治疗相关的食品和药物应用与开发提供了契机。
