短链脂肪酸与癌症
Short-chain fatty acids and cancer.
作者信息
Li Shan, Duan Yixin, Luo Shudi, Zhou Fangxin, Wu Qingang, Lu Zhimin
机构信息
Zhejiang Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang Key Laboratory of Frontier Medical Research on Cancer Metabolism, and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310029, China; Institute of Fundamental and Transdisciplinary Research, Cancer Center, Zhejiang University, Hangzhou, Zhejiang 310029, China.
Department of Oncology, Cancer Institute of The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao Cancer Institute, Qingdao, Shandong 266071, China.
出版信息
Trends Cancer. 2025 Feb;11(2):154-168. doi: 10.1016/j.trecan.2024.11.003. Epub 2024 Dec 4.
Short-chain fatty acids (SCFAs), derived from the diet and the microbiota, serve as crucial links between the diet, gut microbiota, metabolism, immunity, and cancer. They function as energy sources through β-oxidation and regulate macromolecular synthesis, G protein-coupled receptor (GPCR) and histone deacetylase (HDAC) activities, protein modifications, signaling pathways, and gene expression in cells within the tumor microenvironment, particularly in tumor and immune cells. The critical role of SCFAs in maintaining normal homeostasis and influencing tumor progression highlights the potential of targeting SCFA-mediated cellular processes for cancer prevention and treatment.
源自饮食和微生物群的短链脂肪酸（SCFAs）是饮食、肠道微生物群、新陈代谢、免疫和癌症之间的关键纽带。它们通过β-氧化作用充当能量来源，并调节肿瘤微环境中细胞内的大分子合成、G蛋白偶联受体（GPCR）和组蛋白脱乙酰酶（HDAC）活性、蛋白质修饰、信号通路以及基因表达，尤其是在肿瘤细胞和免疫细胞中。短链脂肪酸在维持正常体内平衡和影响肿瘤进展方面的关键作用凸显了针对短链脂肪酸介导的细胞过程进行癌症预防和治疗的潜力。
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